지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 131 - 136 (6page)
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초록· 키워드
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Pain symptoms are a common complication of diabetic peripheral neuropathy or an inflammatory condition. In the most experiments, only one or two evident pain modalities are observed at diabetic peripheral neuropathy according to experimental conditions. Following diabetic peripheral neuropathy or inflammation, spinal glial activation may be considered as an important mediator in the development of pain. For this reason, the present study was aimed to address the induction of pain modalities and spinal glial expression after streptozotocin injection as compared with that of zymosan inflammation in the rat. Evaluation of pain behavior by either thermal or mechanical stimuli was performed at 3 weeks or 5 hours after either intravenous streptozotocin or zymosan. Degrees of pain were divided into 4 groups: severe, moderate, mild, and non-pain induction. On the mechanical allodynia test, zymosan evoked predominantly a severe type of pain, whereas streptozotocin induced a weak degree of pain (severe+moderate: 57.1%). Although zymosan did not evoke cold allodynia, streptozotocin evoked stronger pain behavior, compared with zymosan (severe+moderate: 50.0%). On the other hand, the high incidence of thermal hyperalgesia (severe+moderate: 90.0%) and mechanical hyperalgesia (severe+moderate: 85.7%) by streptozotocin was observed, as similar to that of zymosan. In the spinal cord, the increase of microglia and astrocyte was evident by streptozotocin, only microglia was activated by zymosan. Therefore, it is recommended that the selection of mechanical and thermal hyperalgesia is suitable for the evaluation of streptozotocin induced diabetic peripheral neuropathy. Moreover, spinal glial activation may be considered an important factor.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (18)
참고문헌 신청
1. [학술지(정기간행물)] - Coppey LJ / 2000 / Slowing of motor nerve conduction velocity in streptozotocininduced diabetic rats is preceded by impaired vasodilation in arterioles that overlie the sciatic nerve / Int J Exp Diabetes Res 1 (2) : 131 ~ 143
2. [학술지(정기간행물)] - Obrosova IG / 2009 / Diabetic painful and insensate neuropathy: pathogenesis and potential treatments / Neurotherapeutics 6 (4) : 638 ~ 647
3. [학술지(정기간행물)] - Morrow TJ / 2004 / Animal models of painful diabetic neuropathy: the STZ rat model / Curr Protoc Neurosci
4. [학술지(정기간행물)] - Chen SR / 2009 / Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain / Neuropharmacology 57 (2) : 121 ~ 126
5. [학술지(정기간행물)] - Mixcoatl-Zecuatl T / 2011 / A spinal mechanism of action for duloxetine in a rat model of painful diabetic neuropathy / Br J Pharmacol 164 (1) : 159 ~ 169
2. [학술지(정기간행물)] - Obrosova IG / 2009 / Diabetic painful and insensate neuropathy: pathogenesis and potential treatments / Neurotherapeutics 6 (4) : 638 ~ 647
3. [학술지(정기간행물)] - Morrow TJ / 2004 / Animal models of painful diabetic neuropathy: the STZ rat model / Curr Protoc Neurosci
4. [학술지(정기간행물)] - Chen SR / 2009 / Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain / Neuropharmacology 57 (2) : 121 ~ 126
5. [학술지(정기간행물)] - Mixcoatl-Zecuatl T / 2011 / A spinal mechanism of action for duloxetine in a rat model of painful diabetic neuropathy / Br J Pharmacol 164 (1) : 159 ~ 169
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UCI(KEPA) : I410-ECN-0101-2013-510-002637161