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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 91 - 97 (7page)
이용수
이 논문의 연구 히스토리 (2)
2012
Synergistic anti-inflammatory effects of Laminaria japonica fucoidan and Cistanche tubulosa extract
Jangbeen Kyung
,
Dajeong Kim
,
Dongsun Pa
외 4명
한국실험동물학회 학술발표대회 논문집
2012.08
학술대회자료
Synergistic anti-inflammatory effects of Laminaria japonica fucoidan and Cistanche tubulosa extract
Jangbeen Kyung
,
Dajeong Kim
,
Dongsun Pa
외 7명
Laboratory Animal Research
2012.06
학술저널
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초록· 키워드
오류제보하기
The anti-inflammatory effects of fuciodan and Cistanche tubulosa (CT) extract were investigated in vitro macrophage culture system and in vivo carrageenan-induced air pouch inflammation model. CT extract inhibited nitric oxide production from activated RAW 264.7 macrophage cells, while fucoidan was inactive. In vivo air pouch inflammation model, carrageenan-induced vascular exudation and increased nitric oxide and prostaglandin E2 concentrations in the exudates were synergistically suppressed by co-administration of fucoidan or CT extract. Moreover, tissue inflammation was substantially attenuated by the combinational therapy. However, there was no synergistic effect against the inflammatory cell infiltration, although fucoidan and CT extract each markedly reduced the cell numbers. Therefore, it is suggested that fucoidan blocks infiltration of inflammatory cells, while CT extract inhibits activation of the cells, and that their combinational treatment could be a promising candidate for the relief of various types of inflammation.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (31)
참고문헌 신청
Day R / 2002 / Adverse reactions to TNF-α inhibitors in rheumatoid arthritis / Lancet 359(9306):540~541
Feldmann M / 1996 / Role of cytokines in rheumatoid arthritis / Annu Rev Immunol 14:397~400
Eigler A / 1997 / Taming TNF: strategies to restrain this proinflammatory cytokine / Immunol Today 18(10):487~492
Ershler WB / 2000 / Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty / Annu Rev Med 51:245~270
Adams V / 2002 / Induction of iNOS expression in skeletal muscle by IL-1β and NFκB activation: an in vitro and in vivo study / Cardiovasc Res 54(1):95~104
Feldmann M / 1996 / Role of cytokines in rheumatoid arthritis / Annu Rev Immunol 14:397~400
Eigler A / 1997 / Taming TNF: strategies to restrain this proinflammatory cytokine / Immunol Today 18(10):487~492
Ershler WB / 2000 / Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty / Annu Rev Med 51:245~270
Adams V / 2002 / Induction of iNOS expression in skeletal muscle by IL-1β and NFκB activation: an in vitro and in vivo study / Cardiovasc Res 54(1):95~104
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