지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 77 - 82 (6page)
이용수
초록· 키워드
오류제보하기
Ginkgo biloba extract (EGb 761) exerts a neuroprotective effect against ischemic brain injury through an anti-apoptotic mechanism. Parvalbumin is a calcium buffering protein that plays an important role in modulating intracellular calcium concentration and regulating apoptotic cell death. The aim of this study was to investigate whether EGb 761 affects parvalbumin expression in cerebral ischemic injury. Adult male Sprague-Dawley rats were treated with vehicle or EGb 761 (100 ㎎/㎏) prior to middle cerebral artery occlusion (MCAO) and cerebral cortex tissues were collected 24 h after MCAO. A proteomic approach revealed a reduction in parvalbumin expression in the vehicle-treated animals, whereas EGb 761 pretreatment attenuates the ischemic injury-induced decrease in parvalbumin expression. RT-PCR and Western blot analyses clearly confirmed the fact that EGb 761 prevents the injury-induced decrease in parvalbumin. Moreover, the results of immunohistochemical staining showed that the number of parvalbumin-positive cells was lower in vehicle-treated animals than in sham-operated animals, and EGb 761 averted this decrease. Thus, these results suggest that the maintenance of parvalbumin expression is associated with the neuroprotective function of EGb 761 against neuronal damage induced by ischemia.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (21)
참고문헌 신청
Seif-El-Nasr M / 1995 / Lipid peroxide, phospholipids, glutathione levels and superoxide dismutase activity in rat brain after ischaemia: effect of ginkgo biloba extract / Pharmacol Res 32(5):273~278
Calapai G / 2000 / Neuroprotective effects of Ginkgo biloba extract in brain ischemia are mediated by inhibition of nitric oxide synthesis / Life Sci 67(22):2673~2683
Maurer K / 1997 / Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type / J Psychiatr Res 31(6):645~655
Oken BS / 1998 / The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease / Arch Neurol 55(11):1409~1415
Kotil K / 2008 / Investigation of the dose-dependent antivasospasmic effect of Ginkgo biloba extract (EGb 761) in experimental subarachnoid hemorrhage / J Clin Neurosci 15(12):1382~1386
Calapai G / 2000 / Neuroprotective effects of Ginkgo biloba extract in brain ischemia are mediated by inhibition of nitric oxide synthesis / Life Sci 67(22):2673~2683
Maurer K / 1997 / Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type / J Psychiatr Res 31(6):645~655
Oken BS / 1998 / The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease / Arch Neurol 55(11):1409~1415
Kotil K / 2008 / Investigation of the dose-dependent antivasospasmic effect of Ginkgo biloba extract (EGb 761) in experimental subarachnoid hemorrhage / J Clin Neurosci 15(12):1382~1386
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2013-510-002637090