지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 112 - 122 (11page)
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A gradual change of molecules that are related in fission and fusion is occurred during aging process. Although aging effects on mitochondrial fusion and fission are investigated, it is still unclear that the extent of the change in mitochondria fusion and fission periodically. In this study we investigated the changes of mitochondrial proteins involved in fusion (Mfn2, Opa1) and fission (Drp1, Fis1) in the human gracilis muscle ranging from 10 to 50 years of age (n=40). The gracilis muscle showed a significant increase in muscle apoptotic changes in the age of 50s compared with 10s by using in situ terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL). The expression levels of Drp1 and Fis1 (P<0.01, P<0.05) mRNA were significantly elevated and the Mfn2 and Opa1 (P<0.01, P<0.05) levels were decreased from older individuals. The ratio of fission and fusion was altered and the level of increment of fission gene was greater than fusion gene decrement in the age of 50s. These findings suggest that changes of mitochondrial fusion and fission proteins related with aging might contribute to aged muscle apoptosis.
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REFERENCES
참고문헌 (31)
참고문헌 신청
Alexander C / 2000 / OPA1, encoding a dynaminrelated GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28 / Nat Genet 26:211~215
Bach D / 2005 / Expression of Mfn2, the Charcot-Marie- Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6 / Diabetes 54:2685~2693
Bossy-Wetzel E / 2003 / Mitochondrial fission in apoptosis, neurodegeneration and aging / Curr Opin Cell Biol 15:706~716
Chen H / 2004 / Mitochondiral dynamics in mammals / Curr Top Dev Biol 59:119~144
Chen H / 2007 / Mitochondrial fusion protects against neurodegeneration in the cerebellum / Cell 130:548~562
Bach D / 2005 / Expression of Mfn2, the Charcot-Marie- Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6 / Diabetes 54:2685~2693
Bossy-Wetzel E / 2003 / Mitochondrial fission in apoptosis, neurodegeneration and aging / Curr Opin Cell Biol 15:706~716
Chen H / 2004 / Mitochondiral dynamics in mammals / Curr Top Dev Biol 59:119~144
Chen H / 2007 / Mitochondrial fusion protects against neurodegeneration in the cerebellum / Cell 130:548~562
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UCI(KEPA) : I410-ECN-0101-2013-510-002648606