지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Hypertension is a complex disease that results from the interaction of genetic and environmental influences and heritability is influenced by about one-third to one-half. However, the specific genetic variants determining risk for hypertension are still largely unknown. Here, we performed association analysis to elucidate the possible relations of genetic polymorphisms in ESR1 gene with blood pressure traits. By examining genotype data of a total of 3,804 women in the Korean Association REsource (KARE) study, we discovered the ESR1 gene polymorphisms are associated with blood pressure and hypertension. The highest significant polymorphisms were rs2982571 (β=-1.56, P=6.8 × 10-3) with systolic blood pressure (SBP), rs9322335 (β=-0.61, P=0.013) with diastolic blood pressure (DBP), and rs851985 (OR=0.78, CI: 0.65~0.94, P=8.6 × 10-3) with hypertension. In the 5 SNPs (rs2982571, rs851985, rs851983, rs851981, and rs851980), their β-values in SBP and/or DBP showed consistent trends with the odds ratios (ORs) of hypertension, and these 5 SNPs were composed with one LD block. Consequently, we found statistically significant SNPs in ESR1 gene that are associated with both blood pressure and hypertension traits. These results suggested that the individuals with the minor alleles of the 5 SNPs in the ESR1 gene may be less susceptible to the development of hypertension in the Korean women.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
Acknowledgements
Competing interests
REFERENCES
참고문헌 (26)
참고문헌 신청
Barrett JG / 2005 / Haploview: Analysis and visualization of LD and haplotype maps / Bioinformatics 21:263~265
Brouchet L / 2001 / Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor α but not estrogen receptor β / Circulation 103:423~428
Cho YS / 2009 / A large-scale genomewide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nat Genet 41:527~534
Dubey RK / 2002 / Sex hormones and hypertension / Cardiovasc Res 53:688~708
Figtree GA / 2007 / Novel estrogen receptor alpha promoter polymorphism increases ventricular hypertrophic response to hypertension / J Steroid Biochem Mol Biol 103:110~118
Brouchet L / 2001 / Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor α but not estrogen receptor β / Circulation 103:423~428
Cho YS / 2009 / A large-scale genomewide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nat Genet 41:527~534
Dubey RK / 2002 / Sex hormones and hypertension / Cardiovasc Res 53:688~708
Figtree GA / 2007 / Novel estrogen receptor alpha promoter polymorphism increases ventricular hypertrophic response to hypertension / J Steroid Biochem Mol Biol 103:110~118
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UCI(KEPA) : I410-ECN-0101-2013-510-002648575