지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.6
- 수록면
- 467 - 472 (6page)
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Purpose: The wild-type p53 protein participates in suppressing cell transformations while its mutant forms has tumorigenic potential. Alterations in the structure of the p53 protein are one of the most common changes associated with human cancers. CREB-binding protein (CBP) and its homologue, p300, are transcriptional co-activators of various sequence-specific DNA-binding transcription factors and are involved in a wide range of cellular activities, such as DNA repair, cell growth, differentiation, and apoptosis. Several studies suggested that an association between p53 and p300 might account for the p53-responsible negative regulation. This study examined the relationship between p53 and CBP expression in terms of the clinicopathological factors and significance.
Methods: The level of p53 protein and CBP expression was measured in 150 gastric adenocarcinoma patients, who had undergone a gastrectomy, and the relationship between p53 and CBP was examined. Immunohistochemical stain was performed on formalin-fixed paraffin-embedded sections using monoclonal anti-p53 and anti-CBP antibody.
Results: 1. p53 protein was expressed in 46.3% (31/67) of early gastric cancers (EGC), 69.9% (58/83) of advanced gastric cancers (AGC)(P＜0.05), 69.1% (65/94) of the intestinal type, 42.9% (24/56) of the diffuse type (P＜0.05), 78.5% (55/70) of patients with a lymph node metastasis and 42.5% (34/80) of patients without a lymph node metastasis (P＜0.01). 2. CBP expression was observed in 65% (61/94) of intestinal type, 51% (29/56) of the diffuse type (P＞0.05), 47.8% (32/67) of EGC, 69.8% (58/83) of AGC (P＜0.05), 68.6% (48/70) of patients with a lymph node metastasis and 52.5% (42/80) of patients without a lymph node metastasis (P＞0.05). 3. p53 protein and CBP expression was coincidentally observed in 66.7% of gastric adenocarcinomas, and there was a significant correlation between the expression of both (P＜0.05).
Conclusion: That the expression of the p53 protein and CBP indirectly indicate the malignant potential of a cell, and may play an indirect role in the CBP and p53-mediated tumorigenic potential.
Methods: The level of p53 protein and CBP expression was measured in 150 gastric adenocarcinoma patients, who had undergone a gastrectomy, and the relationship between p53 and CBP was examined. Immunohistochemical stain was performed on formalin-fixed paraffin-embedded sections using monoclonal anti-p53 and anti-CBP antibody.
Results: 1. p53 protein was expressed in 46.3% (31/67) of early gastric cancers (EGC), 69.9% (58/83) of advanced gastric cancers (AGC)(P＜0.05), 69.1% (65/94) of the intestinal type, 42.9% (24/56) of the diffuse type (P＜0.05), 78.5% (55/70) of patients with a lymph node metastasis and 42.5% (34/80) of patients without a lymph node metastasis (P＜0.01). 2. CBP expression was observed in 65% (61/94) of intestinal type, 51% (29/56) of the diffuse type (P＞0.05), 47.8% (32/67) of EGC, 69.8% (58/83) of AGC (P＜0.05), 68.6% (48/70) of patients with a lymph node metastasis and 52.5% (42/80) of patients without a lymph node metastasis (P＞0.05). 3. p53 protein and CBP expression was coincidentally observed in 66.7% of gastric adenocarcinomas, and there was a significant correlation between the expression of both (P＜0.05).
Conclusion: That the expression of the p53 protein and CBP indirectly indicate the malignant potential of a cell, and may play an indirect role in the CBP and p53-mediated tumorigenic potential.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Davessar K / 1990 / Gastric carcinoma: prognostic significance of several pathologic parameters and histologic classification / Hum Pathol 21 : 325 ~ 332
2. [학술지(정기간행물)] - Munoz N / 1968 / Histologic types of gastric carcinoma in high- and low-risk areas / Int J Cancer 3 : 809 ~ 818
3. [학술지(정기간행물)] - Tahara E / 1996 / Molecular biological observations in gastric cancer / Semin Oncol 23 : 307 ~ 315
4. [학술지(정기간행물)] - Zambetti GP / 1993 / A comparison of the biologic activities of wild type and mutant p53 / FASEB J 7 : 855 ~ 862
5. [학술지(정기간행물)] - Goodman RH / 2000 / CBP/p300 in cell growth, transformation and development / Genes Dev 14 : 1553 ~ 1577
2. [학술지(정기간행물)] - Munoz N / 1968 / Histologic types of gastric carcinoma in high- and low-risk areas / Int J Cancer 3 : 809 ~ 818
3. [학술지(정기간행물)] - Tahara E / 1996 / Molecular biological observations in gastric cancer / Semin Oncol 23 : 307 ~ 315
4. [학술지(정기간행물)] - Zambetti GP / 1993 / A comparison of the biologic activities of wild type and mutant p53 / FASEB J 7 : 855 ~ 862
5. [학술지(정기간행물)] - Goodman RH / 2000 / CBP/p300 in cell growth, transformation and development / Genes Dev 14 : 1553 ~ 1577
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UCI(KEPA) : I410-ECN-0101-2013-514-002675538