지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.9
- 수록면
- 221 - 226 (6page)
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초록· 키워드
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Purpose: We examined the expressions of claudin-4 and E-cadherin, which are known as cell adhesion-associated proteins, in stomach cancer. The relationship of their expression with the clinicopathologic factors was examined to investigate the roles of these proteins in the invasion or metastasis of stomach adenocarcinoma.
Methods: The expressions of claudin-4 and E-cadherin were examined in 73 cases of adenocarcinoma of the stomach by performing immunohistochemical staining.
Results: The expressions of claudin-4 and E-cadherin in the stomach adenocarcinoma were both correlated with the histologic grade, the T-stage and nodal metastasis, respectively (P＜0.05). The expression of claudin-4 was significantly associated with the expression of E-cadherin.
Conclusion: Our data suggests that claudin-4 and E-cadherin are involved in the processes of histologic differentiation, invasion and metastasis of stomach adenocarcinoma.
Methods: The expressions of claudin-4 and E-cadherin were examined in 73 cases of adenocarcinoma of the stomach by performing immunohistochemical staining.
Results: The expressions of claudin-4 and E-cadherin in the stomach adenocarcinoma were both correlated with the histologic grade, the T-stage and nodal metastasis, respectively (P＜0.05). The expression of claudin-4 was significantly associated with the expression of E-cadherin.
Conclusion: Our data suggests that claudin-4 and E-cadherin are involved in the processes of histologic differentiation, invasion and metastasis of stomach adenocarcinoma.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (27)
참고문헌 신청
Gonzalez-Mariscal L , 2001 , The relationship between structure and function of tight junctions, In Tight Junctions. 2nd ed , CRC Press : 89 ~ 110
Resnick MB , 2005 , Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study , Modern Pathol 18 : 511 ~ 518
Kimura Y , 1997 , Expression of occludin tight junction associated protein in human digestive tract , AM J Pathol 151 : 45 ~ 54
Lee SK , 2005 , Loss of the tight junction protein claudin-4 correlates with histological growth-pattern and differentiation in advanced gastric adenocarcinoma , Oncol Rep 13 : 193 ~ 199
Tsukahara M , 2005 , Distinct expression patterns of claudin-1 and claudin-4 in intraductal papillary-mucinous tumors of the pancreas , Pathol Int 55 : 63 ~ 69
Resnick MB , 2005 , Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study , Modern Pathol 18 : 511 ~ 518
Kimura Y , 1997 , Expression of occludin tight junction associated protein in human digestive tract , AM J Pathol 151 : 45 ~ 54
Lee SK , 2005 , Loss of the tight junction protein claudin-4 correlates with histological growth-pattern and differentiation in advanced gastric adenocarcinoma , Oncol Rep 13 : 193 ~ 199
Tsukahara M , 2005 , Distinct expression patterns of claudin-1 and claudin-4 in intraductal papillary-mucinous tumors of the pancreas , Pathol Int 55 : 63 ~ 69
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UCI(KEPA) : I410-ECN-0101-2013-514-002673110