지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.7
- 수록면
- 25 - 34 (10page)
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초록· 키워드
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Purpose: To evaluate the comparative therapeutic efficacy of radiofrequency ablation (RFA) and hepatic resection for the treatment of colorectal liver metastasis (CRLM). Methods: Between 1996 and 2008, 177 patients underwent RFA, 278 underwent hepatic resection and 27 underwent combination therapy for CRLM. Comparative analysis of clinical outcomes was performed including number of liver metastases, tumor size, and time of CRLM. Results: Based on multivariate analysis, overall survival (OS) correlated with the number of liver metastases and the use of combined chemotherapy (P ＜ 0.001, respectively). Disease-free survival (DFS) also correlated with the number of liver metastases (P ＜ 0.001). In the 226 patients with solitary CRLM ＜ 3 cm, OS and DFS rates did not differ between the RFA group and the resection group (P = 0.962 and P = 0.980). In the 70 patients with solitary CRLM ≥ 3 cm, DFS was significantly lower in the RFA group as compared with the resection group (P = 0.015). Conclusion: The results indicate that RFA may be a safe alternative treatment for solitary CRLM less than 3 cm, with outcomes equivalent to those achieved with hepatic resection. A randomized controlled study comparing RFA and resection for patients with single small metastasis would help to determine the most efficient treatment modalities for CRLM.
목차
Purpose
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONFLICTS OF INTEREST
REFERENCES
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Scheele J / 1995 / Resection of colorectal liver metastases / World J Surg 19 : 59 ~ 71
2. [학술지(정기간행물)] - Wilson SM / 1976 / Surgical treatment of hepatic metastases from colorectal cancers / Arch Surg 111 : 330 ~ 334
3. [학술지(정기간행물)] - Aloia TA / 2006 / Solitary colorectal liver metastasis: resection determines outcome / Arch Surg 141 : 460 ~ 466
4. [학술지(정기간행물)] - Mulier S / 2008 / Radiofrequency ablation versus resection for resectable colorectal liver metastases: time for a randomized trial / Ann Surg Oncol 15 : 144 ~ 157
5. [학술지(정기간행물)] - Feliberti EC / 2006 / Radiofrequency ablation of liver metastases from colorectal carcinoma / Cancer Control 13 : 48 ~ 51
2. [학술지(정기간행물)] - Wilson SM / 1976 / Surgical treatment of hepatic metastases from colorectal cancers / Arch Surg 111 : 330 ~ 334
3. [학술지(정기간행물)] - Aloia TA / 2006 / Solitary colorectal liver metastasis: resection determines outcome / Arch Surg 141 : 460 ~ 466
4. [학술지(정기간행물)] - Mulier S / 2008 / Radiofrequency ablation versus resection for resectable colorectal liver metastases: time for a randomized trial / Ann Surg Oncol 15 : 144 ~ 157
5. [학술지(정기간행물)] - Feliberti EC / 2006 / Radiofrequency ablation of liver metastases from colorectal carcinoma / Cancer Control 13 : 48 ~ 51
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UCI(KEPA) : I410-ECN-0101-2013-514-002684928