지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.5
- 수록면
- 301 - 306 (6page)
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Purpose: No clinically useful target molecule has been identified for triple-negative (TN) breast cancer, i.e., estrogen receptor- negative, progesterone receptor-negative, human epidermal growth factor receptor-2-negative phenotype, and its prognosis is poor. The aim of this study is to clarify the clinical and pathologic characteristics of triple negative breast cancer (TNBC). Methods: The study subjects, 87 women with TNBC, were a subset of patients operated at Kosin University Gospel Hospital from January 2000 to December 2005. We examined pathologic characteristics such as tumor necrosis, infiltrating border, lymphocytic infiltration, prominent nucleoli in TNBC. And we studied the correlation between TNBC and several factors related to pathologic morphology. Chi-squared tests were used for statistical analysis. Kaplan-Meier estimates are presented for the survival function, and differences in survival were analyzed using the log rank test. Results: Tumor necrosis was found in 51 patients (58.3%) in TNBC. And infiltrating border was found in 71 patients (81.0%). Also continuous lymphocytic distribution and prominent nucleoli was found in 31 patients (35.7%), 52 patients (59.7%), respectively. No association was detected between pathologic characteristics and other biological markers. Patients with tumor necrosis positive for TNBC didn’t show shorter disease-free survival (P = 0.4490) or overall survival (P = 0.979) than patients without tumor necrosis. Conclusion: These findings suggest that pathologic characteristics cannot be used to classify triple-negative breast cancer into only two subtypes with differing prognoses. But because our study is small size study, more abundant patients’ dates will be needed to evaluate the morphologic characteristics’ predictive role.
목차
Purpose
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONFLICTS OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Perou CM / 2000 / Molecular portraits of human breast tumours / Nature 406 : 747 ~ 752
2. [학술지(정기간행물)] - Sørlie T / 2001 / Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications / Proc Natl Acad Sci U S A 98 : 10869 ~ 10874
3. [학술지(정기간행물)] - Carey LA / 2006 / Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study / JAMA 295 : 2492 ~ 2502
4. [학술지(정기간행물)] - Rakha EA / 2008 / Basal-like breast cancer: a critical review / J Clin Oncol 26 : 2568 ~ 2581
5. [학술지(정기간행물)] - Hicks DG / 2006 / Breast cancers with brain metastases are more likely to be estrogen receptor negative, express the basal cytokeratin CK5/6, and overexpress HER2 or EGFR / Am J Surg Pathol 30 : 1097 ~ 1104
2. [학술지(정기간행물)] - Sørlie T / 2001 / Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications / Proc Natl Acad Sci U S A 98 : 10869 ~ 10874
3. [학술지(정기간행물)] - Carey LA / 2006 / Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study / JAMA 295 : 2492 ~ 2502
4. [학술지(정기간행물)] - Rakha EA / 2008 / Basal-like breast cancer: a critical review / J Clin Oncol 26 : 2568 ~ 2581
5. [학술지(정기간행물)] - Hicks DG / 2006 / Breast cancers with brain metastases are more likely to be estrogen receptor negative, express the basal cytokeratin CK5/6, and overexpress HER2 or EGFR / Am J Surg Pathol 30 : 1097 ~ 1104
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UCI(KEPA) : I410-ECN-0101-2013-514-002684135