지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 397 - 403 (7page)
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초록· 키워드
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Purpose: Cyclooxygenase-2 is believed to be an important enzyme in the pathogenesis of colorectal cancer (CRC). Cytosolic phospholipase A2 (cPLA2), also, have been suggested to be related to the carcinogenesis of CRC. The aim of this study was to investigate cPLA2 expression and its relationship with prognostic significance in CRC. Methods: Eighty-eight patients with colorectal cancer who underwent curative surgery were enrolled in this study. cPLA2 was examined in 88 primary CRCs by immunohistochemistry and we compared their expression with clinicopathologic findings, recurrence and survival in patients with CRC. Results: The expression of cPLA2 was positive in 54.5% (48/88). The expression of cPLA2 was not correlated with clinicopathologic parameters. However, cPLA2 expression was significantly related with vascular endothelial growth factor expression. Kaplan-Meier analysis didn’t show any clinical significance in disease-free survival and overall survival according to cPLA2 expression. Conclusion: These results suggest that cPLA2 expression was not associated with the prognosis of CRC. However, further large-scale studies are needed to clarify the prognostic effect of cPLA2 in CRC.
목차
Purpose
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONFLICTS OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Boyle P / 1985 / Descriptive epidemiology of colorectal cancer / Int J Cancer 36 : 9 ~ 18
2. [학술지(정기간행물)] - Boyle P / 2002 / Epidemiology of colorectal cancer / Br Med Bull 64 : 1 ~ 25
3. [보고서] - Ministry for Health, Welfare and Family Affairs / 2009 / Annual report of cancer incidence (2007), cancer prevalence (2007) and survival (1993-2007) in Korea
4. [학술지(정기간행물)] - Williams CS / 1999 / The role of cyclooxygenases in inflammation, cancer, and development / Oncogene 18 : 7908 ~ 7916
5. [학술지(정기간행물)] - Balsinde J / 1999 / Regulation and inhibition of phospholipase A2 / Annu Rev Pharmacol Toxicol 39 : 175 ~ 189
2. [학술지(정기간행물)] - Boyle P / 2002 / Epidemiology of colorectal cancer / Br Med Bull 64 : 1 ~ 25
3. [보고서] - Ministry for Health, Welfare and Family Affairs / 2009 / Annual report of cancer incidence (2007), cancer prevalence (2007) and survival (1993-2007) in Korea
4. [학술지(정기간행물)] - Williams CS / 1999 / The role of cyclooxygenases in inflammation, cancer, and development / Oncogene 18 : 7908 ~ 7916
5. [학술지(정기간행물)] - Balsinde J / 1999 / Regulation and inhibition of phospholipase A2 / Annu Rev Pharmacol Toxicol 39 : 175 ~ 189
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UCI(KEPA) : I410-ECN-0101-2013-514-002684059