A missense polymorphism (rs11895564, Ala380Thr) of integrin alpha 6 is associated with the development and progression of papillary thyroid carcinoma in Korean population

Su Kang Kim; Dong Kwan Kim; In-Hwan Oh; Jeong Yoon Song; Kee Hwan Kwon; Bong-Keun Choe; Yong Ho Kim

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저자정보: Su Kang Kim (Kohwang Medical Research Institute) Dong Kwan Kim (Kyung Hee University) In-Hwan Oh (Kyung Hee University) Jeong Yoon Song (Kyung Hee University) Kee Hwan Kwon (Kyung Hee University) Bong-Keun Choe (Kyung Hee University) Yong Ho Kim (Kyung Hee University)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research 대한외과학회지 Vol.81 No.5

발행연도: 2011.11

수록면: 308 - 315 (8page)

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Purpose: Integrins play crucial roles in the pathogenesis of papillary thyroid carcinoma (PTC). The aim of this study was to investigate whether two single nucleotide polymorphisms (SNPs) (rs2141698, -1687A/G; rs11895564, Ala380Thr) of the integrin alpha 6 (ITGA6) gene are associated with the development and clinicopathologic characteristics of PTC such as the size (＜1 cm and ≥1 cm), number (unifocality and multifocality), location (one lobe and both lobes), extrathyroid invasion, and cervical lymph node metastasis. Methods: We enrolled 104 PTC patients and 318 control subjects. Genotypes of each SNP were determined by direct sequencing. SNPStats, SNPAnalyzer, and Helixtree programs were used to evaluate odds ratios (ORs), 95% confidence intervals (CIs), and P-values. Multiple logistic regression models were performed to analyze genetic data. Results: A missense SNP rs11895564 was associated with the development of PTC. The A allele frequency of rs11895564 was higher in PTC patients than in controls (13.5% vs. 7.1%; P = 0.005; OR, 2.04; 95% CI, 1.24 to 3.37). In the clinicopathologic characteristics, the A allele frequency of rs11895564 showed difference in the size (19.6% in ＜1 cm vs. 6.9% in ≥1 cm; P = 0.010; OR, 0.30; 95% CI, 0.12 to 0.75) and number (8.5% in unifocality vs. 20.8% in multifocality; P = 0.015; OR, 2.85; 95% CI, 1.23 to 6.59) of PTC. Conclusion: These results suggest that the A allele of rs11895564 (Ala380Thr) in ITGA6 may be a risk factor of PTC, and also contribute to the progression of PTC in the Korean population.

#Integrins #alpha 6 (ITGA6) #Papillary thyroid cancer #Polymorphism #Progression

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