지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.2
- 수록면
- 87 - 93 (7page)
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Purpose: Locally advanced rectal cancer may require an intraoperative decision regarding curative multivisceral resection (MVR) of adjacent organs. In bulky tumor cases, ensuring sufficient distal resection margin (DRM) for achievement of oncologic safety is very difficult. This study is designed to evaluate the adequate length of DRM in multiviscerally resected rectal cancer. Methods: A total of 324 patients who underwent curative low anterior resection for primary pT3-4 rectal cancer between 1995 and 2004 were identified from a prospectively collected colorectal database. Results: Short lengths of DRM (≤1 ㎝) did not compromise essentially poor oncologic outcomes in locally advanced rectal cancer (P = 0.736). However, especially in rectal cancers invading adjacent organs, DRM of less than 2 cm showed poor survival outcome. In 5-year and 10-year survival analysis of MVR, a shorter DRM (＜2 ㎝) showed 41.9% and 30.5%, although a longer DRM (≥2 ㎝) showed 72.4% and 60.2% (P = 0.03, 0.044). In multivariate analysis of MVR, poorly differentiated histology, ulceroinfiltrative growth of tumor, and short DRM (＜2 ㎝) were significant factors for prediction of poor survival outcome, although short DRM was not significantly related to local and systemic recurrence. Conclusion: In locally advanced rectal cancer of pT3-4, a short length of DRM (≤1 ㎝) did not compromise essentially poor oncologic outcome. In rectal cancers invading adjacent organs and requiring MVR, a shorter DRM (＜2 ㎝) was found to be related to poor survival outcome.
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INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONFLICTS OF INTEREST
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UCI(KEPA) : I410-ECN-0101-2013-514-002677714