지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.3
- 수록면
- 165 - 171 (7page)
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초록· 키워드
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Purpose: Currently, circumferential resection margins (CRM) are used as a clinical endpoint in studies on the prognosis of rectal cancer. Although the concept of a circumferential resection margin in extraperitoneal rectal cancer differs from that in intraperitoneal rectal cancer due to differences in anatomical and biologic behaviors, previous reports have provided information on CRM involvement in all types of rectal cancer including intraperitoneal lesions. Therefore, the aim of this study was to analyze risk factors of CRM involvement in extraperitoneal rectal cancer. Methods: From January 2005 to December 2008, 306 patients with extraperitoneal rectal cancer were enrolled in a prospectively collected database. Multivariate logistic regression analysis was used to identify predictors of CRM involvement. Results: The overall rate of CRM involvement was found to be 16.0%. Multivariate analysis showed that male sex, larger tumor size (≥4 ㎝), stage higher than T3, nodal metastasis, tumor perforation and non-sphincter preserving proctectomy (NSPP) were risk factors for CRM involvement. Conclusion: Male sex, larger tumor size (≥4 ㎝), advanced T stage, nodal metastasis, tumor perforation, and NSPP are significant risk factors of CRM involvement in extraperitoneal rectal cancer. Given that postoperative chemoradiotherapy is recommended for patients with a positive CRM, further oncologic studies are warranted to ascertain which patients with these risk factors would require adjuvant therapy.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONFLICTS OF INTEREST
REFERENCES
참고문헌 (21)
참고문헌 신청
1. [학술지(정기간행물)] - Nagtegaal ID / 2002 / Circumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma: not one millimeter but two millimeters is the limit / Am J Surg Pathol 26 : 350 ~ 357
2. [학술지(정기간행물)] - Tekkis PP / 2005 / Comparison of circumferential margin involvement between restorative and nonrestorative resections for rectal cancer / Colorectal Dis 7 : 369 ~ 374
3. [학술지(정기간행물)] - Sebag-Montefiore D / 2009 / Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial / Lancet 373 : 811 ~ 820
4. [학술지(정기간행물)] - Nagtegaal ID / 2008 / What is the role for the circumferential margin in the modern treatment of rectal cancer? / J Clin Oncol 26 : 303 ~ 312
5. [학술지(정기간행물)] - den Dulk M / 2007 / Quality of surgery in T3-4 rectal cancer: involvement of circumferential resection margin not influenced by preoperative treatment. Results from EORTC trial 22921 / Eur J Cancer 43 : 1821 ~ 1828
2. [학술지(정기간행물)] - Tekkis PP / 2005 / Comparison of circumferential margin involvement between restorative and nonrestorative resections for rectal cancer / Colorectal Dis 7 : 369 ~ 374
3. [학술지(정기간행물)] - Sebag-Montefiore D / 2009 / Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial / Lancet 373 : 811 ~ 820
4. [학술지(정기간행물)] - Nagtegaal ID / 2008 / What is the role for the circumferential margin in the modern treatment of rectal cancer? / J Clin Oncol 26 : 303 ~ 312
5. [학술지(정기간행물)] - den Dulk M / 2007 / Quality of surgery in T3-4 rectal cancer: involvement of circumferential resection margin not influenced by preoperative treatment. Results from EORTC trial 22921 / Eur J Cancer 43 : 1821 ~ 1828
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UCI(KEPA) : I410-ECN-0101-2013-514-002677274