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논문 기본 정보

자료유형
학술저널
저자정보
Yong-Hae Baik (동국대학교 일산병원) Ji Yeong An (연세대학교 세브란스병원) Jae-Hyung Noh (성균관대학교) Tae-Sung Sohn (성균관대학교) Sung Kim (성균관대학교)
저널정보
대한외과학회 Annals of Surgical Treatment and Research 대한외과학회지 Vol.82 No.3
발행연도
2012.3
수록면
143 - 148 (6page)

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Purpose: Although local resection like endoscopic mucosal resection for early gastric cancer is accepted as a treatment option, one of the most important drawbacks of such an approach is the inability to predictlymph node metastasis. The aim of this study was to evaluate the serum soluble receptor alpha for interleukin-2 (IL-2Rα) level as a predictor of lymph node metastasis in the patients with early gastric cancer. Methods: Assessment of pre-operative serum IL-2Rα levels was performed on 86 patients with early gastric cancer treated by gastrectomies combined with D2 lymph node resections and 20 healthy controls at Samsung Medical Center. Data on patient age and gender, tumor size, depth of invasion, histologic differentiation, and endoscopic findings were reviewed post-operatively. The submucosal lesions were divided into three layers (sm1, sm2, and sm3) in accordance with the depth of invasion. Results: Lymph node metastasis was observed in 16 patients (18.6%). Statistically, the serum IL-2Rα level was an important predictive factor of lymph node metastasis in undifferentiated gastric cancer, and the cut-off point for the predictive value of serum IL-2Rα level was 200 U/mL. Conclusion: The serum IL-2Rα level might be a good predictor of lymph node metastasis in undifferentiated early gastric cancer.

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UCI(KEPA) : I410-ECN-0101-2013-514-002677249