지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 93 - 98 (6page)
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초록· 키워드
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This study has attempted to establish an analysis method through validation against heavy metals in the body (Pb, Cd and Hg) using ICP-MS and Gold amalgamation and find out the relevance between heavy metal and Alzheimer’s disease after analyzing the distribution of heavy metal concentration (Pb, Cd and Hg) and correlations between a control group and Alzheimer’s disease group. In this study, Pb and Cd levels in the blood and serum were validation using ICP-MS. For analysis of Hg levels in the blood and serum, the gold amalgamation-based ‘Direct Mercury Analyzer’ has been used. According to an analysis on the heavy metal concentration (Pb, Cd and Hg concentration) in the blood, Cd concentration was high in the Alzheimer’s disease group. In the serum, on the contrary, Pb and Hg were high in the Alzheimer’s disease group. For analysis of correlations between heavy metal levels in the blood and serum and Alzheimer’s disease, t-test has been performed. Even though correlations were observed between the blood lead levels and Alzheimer’s disease, they were statistically insignificant because the concentration was higher in a control group. No significance was found in Cd and Hg. In the serum, on the other hand, no statistical significance was found between the heavy metal (Pb, Cd and Hg) and Alzheimer’s disease. In this study, no statistical significance was observed between heavy metal and decrease in cognitive intelligence. However, it appears that a further study needs to be performed because the results of the conventional studies were inconsistent.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENT
REFERENCES
참고문헌 (18)
참고문헌 신청
Ash, K.O / 1997 / Analysis of clinical specimens using inductively coupled plasma mass spectrometry, In Handbook of analytical therapeutic drug monitoring and toxicology / CRC Press Inc
Bocca, B. / 2005 / Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer’s disease / Ann. Ist. Super. Sanita 41:197~203
Bomboi, G. / 2005 / Correlation between metal ions and clinical findings in subjects affected by Alzheimer’s disease / Ann. Ist. Super. Sanita 41:205~212
2009 / British-Adopted European Standard 15763
CDC / 1998 / Laboratory methods fot the Elemental Analysis of blood and Urine Sample
Bocca, B. / 2005 / Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer’s disease / Ann. Ist. Super. Sanita 41:197~203
Bomboi, G. / 2005 / Correlation between metal ions and clinical findings in subjects affected by Alzheimer’s disease / Ann. Ist. Super. Sanita 41:205~212
2009 / British-Adopted European Standard 15763
CDC / 1998 / Laboratory methods fot the Elemental Analysis of blood and Urine Sample
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UCI(KEPA) : I410-ECN-0101-2013-513-002709463