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자료유형
학술저널
저자정보
정동환 (울산대학교) 이승규 (울산대학교) 황신 (울산대학교) 홍혜남 (울산대학교)
저널정보
대한외과학회 Annals of Surgical Treatment and Research 대한외과학회지 Vol.77 No.1
발행연도
2009.7
수록면
15 - 28 (14page)

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Purpose: Most of grafts used as interposition conduits for middle hepatic vein (MHV) in living donor liver transplantation (LDLT) have been allografts and autografts. Recently, polytetrafluoroethylene (PTFE) and bovine pericardium patch have also been used. Thus, we performed large-animal lab tests to assess the feasibility of interposition vessel graft substitutes for MHV.
Methods: The inferior vena cava was replaced in 9 dogs with allograft (3), PTFE (3), and bovine pericardium patch (3). After 28 days, patency rate, outer and inner diameter, intimal thickness, histology, and immunohistochemistry were evaluated according to interposition grafts.
Results: The allograft and PTFE groups were all patent at post-operative week 4, but the bovine group was not patent in all dogs. Outer diameter of anastomotic site at 4 weeks was 8.41±0.37, 10.83±0.51, and 7.41±0.86 mm in allograft, PTFE, and bovine group, respectively. Inner diameter of interposition graft at 4 weeks was 7.90±0.23, 6.33±0.68, and 0 mm in allograft, PTFE, and bovine groups, respectively. Intimal thickness was 48.0±8.6, 113.8±45.3, and 218.3±59.9㎛ in allograft, PTFE, and bovine groups, respectively. In histologic findings, inflammation was most severe in the bovine group. Intima of anastomotic site in the bovine group was thickest in all groups. Proliferation of smooth muscle cells was most severe in anti-alpha-actin antibody test in bovine group.
Conclusion: Our data implicate that the use of allografts and PTFE grafts is more feasible than bovine pericardium for MHV reconstruction in LDLT.

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