지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.7
- 수록면
- 27 - 34 (8page)
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Purpose: The genetic polymorphism and intracellular activity of methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) is clinically associated with carcinogenesis and biological therapeutic effect in gastrointestinal malignancies. We aimed to elucidate the susceptibility of gastric cancer according to MTHFR and TS gene polymorphism.
Methods: This study was designed as a hospital-based case-control study in a single institute. The gastric cancer group (n=300) for the study was diagnosed at first time as tubular adenocarcinoma, and the control group (n=100) was diagnosed as no malignancy in the endoscopic biopsy. The genetic polymorphism of TS and MTHFR were confirmed by PCR.
Results: The MTHFR mutant type had a more than 2-fold increased risk of developing gastric cancer (RR: 2.341). But, only heterozygote type (677CT) revealed significantly higher susceptibility compared to wild type (RR: 2.581). In TS gene genotype, the mutant genotype rate (2R/3R and 3R/3R) was significantly higher in gastric cancer group compared to control group (P=0.008), and the mutant type had a more than 3-fold increased risk of developing gastric cancer (RR: 3.222). In combined MTHFR and TS, 677CT＋2R/3R and 677CT＋3R/3R there was more than a 3-fold increased risk rate of developing gastric cancer compared with other combinations (RR, 3.474 in 677CT with 2R/3R; RR, 3.895 in 677CT with 3R/3R).
Conclusion: This study shows a significant association between the MTHFR and TS polymorphisms and susceptibility to gastric cancer, providing a genetic basis. The polymorphisms study of two genes could be applied as susceptibility markers, clinically, for gastric cancer.
Methods: This study was designed as a hospital-based case-control study in a single institute. The gastric cancer group (n=300) for the study was diagnosed at first time as tubular adenocarcinoma, and the control group (n=100) was diagnosed as no malignancy in the endoscopic biopsy. The genetic polymorphism of TS and MTHFR were confirmed by PCR.
Results: The MTHFR mutant type had a more than 2-fold increased risk of developing gastric cancer (RR: 2.341). But, only heterozygote type (677CT) revealed significantly higher susceptibility compared to wild type (RR: 2.581). In TS gene genotype, the mutant genotype rate (2R/3R and 3R/3R) was significantly higher in gastric cancer group compared to control group (P=0.008), and the mutant type had a more than 3-fold increased risk of developing gastric cancer (RR: 3.222). In combined MTHFR and TS, 677CT＋2R/3R and 677CT＋3R/3R there was more than a 3-fold increased risk rate of developing gastric cancer compared with other combinations (RR, 3.474 in 677CT with 2R/3R; RR, 3.895 in 677CT with 3R/3R).
Conclusion: This study shows a significant association between the MTHFR and TS polymorphisms and susceptibility to gastric cancer, providing a genetic basis. The polymorphisms study of two genes could be applied as susceptibility markers, clinically, for gastric cancer.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - El-Rifai W / 2002 / Molecular biology of gastric cancer / Semin Radiat Oncol 12 : 128 ~ 140
2. [학술지(정기간행물)] - Gonzalez CA / 2002 / Genetic susceptibility and gastric cancer risk / Int J Cancer 100 : 249 ~ 260
3. [학술지(정기간행물)] - Gonzalez CA / 1994 / Nutritional factors and gastric cancer in Spain / Am J Epidemiol 139 : 466 ~ 473
4. [학술지(정기간행물)] - Kim YI / 2000 / Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of gene-nutrient interactions in carcinogenesis / Nutr Rev 58 : 205 ~ 209
5. [학술지(정기간행물)] - Pogribny IP / 1995 / Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl- deficient rats / Cancer Res 55 : 1894 ~ 1901
2. [학술지(정기간행물)] - Gonzalez CA / 2002 / Genetic susceptibility and gastric cancer risk / Int J Cancer 100 : 249 ~ 260
3. [학술지(정기간행물)] - Gonzalez CA / 1994 / Nutritional factors and gastric cancer in Spain / Am J Epidemiol 139 : 466 ~ 473
4. [학술지(정기간행물)] - Kim YI / 2000 / Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of gene-nutrient interactions in carcinogenesis / Nutr Rev 58 : 205 ~ 209
5. [학술지(정기간행물)] - Pogribny IP / 1995 / Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl- deficient rats / Cancer Res 55 : 1894 ~ 1901
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26. A clinical study on 140 cases of early gastric cancer
대한외과학회 학술대회 초록집
1989 .11
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Clinical Study of Early Gastric Cancer
대한외과학회 학술대회 초록집
1987 .11
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