지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 189 - 193 (5page)
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초록· 키워드
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Purpose: Interferon gamma release assays (QuantiFERON-TB Gold in Tube test [QFT-GIT]); Cellestis Limited, Victoria, Australia) have been studied for diagnosing pulmonary tuberculosis (TB) or latent TB but there have been no reports on the usefulness of this assay in diagnosing tuberculous anal fistula in actual clinical practices. In this study, we evaluated its diagnostic usefulness in patients with suspected tuberculous anal fistula.
Methods: We conducted a retrospective analysis of 119 patients with suspected tuberculous anorectal fistula from May 2007 to May 2009. Diagnosis of tuberculous fistula was concluded by identification of acid-fast bacilli, typical caseating granuloma and successful clinical response to anti-TB chemotherapy. All patients underwent the QFT-GIT and all patients diagnosed with tuberculous anal fistula were analyzed.
Results: Of the 119 patients with suspected TB fistula, 51 (43%) patients were classified as having TB fistula, including 31 with confirmed tuberculosis and 20 with probable tuberculosis, and other 68 (57%) were classified as not having tuberculosis. Among the 51 patients with TB fistula, Chronic caseating granuloma, acid-fast bacilli stain, and successful clinical response to anti-TB treatment were positive in 27 (52.9%), 4 (7.8%), and 20 (39.2%), respectively. Of the 51 with TB fistula, 44 had positive QFT-GIT results and 7 had negative results. The sensitivity and specificity of the assay were 86% and 85%, and positive predictive value (PPV) and negative predictive value (NPV) were 81% and 89%, respectively.
Conclusion: QFT-GIT is a simple, sensitive, and specific method for the diagnosis of clinically highly suspected TB fistula.
Methods: We conducted a retrospective analysis of 119 patients with suspected tuberculous anorectal fistula from May 2007 to May 2009. Diagnosis of tuberculous fistula was concluded by identification of acid-fast bacilli, typical caseating granuloma and successful clinical response to anti-TB chemotherapy. All patients underwent the QFT-GIT and all patients diagnosed with tuberculous anal fistula were analyzed.
Results: Of the 119 patients with suspected TB fistula, 51 (43%) patients were classified as having TB fistula, including 31 with confirmed tuberculosis and 20 with probable tuberculosis, and other 68 (57%) were classified as not having tuberculosis. Among the 51 patients with TB fistula, Chronic caseating granuloma, acid-fast bacilli stain, and successful clinical response to anti-TB treatment were positive in 27 (52.9%), 4 (7.8%), and 20 (39.2%), respectively. Of the 51 with TB fistula, 44 had positive QFT-GIT results and 7 had negative results. The sensitivity and specificity of the assay were 86% and 85%, and positive predictive value (PPV) and negative predictive value (NPV) were 81% and 89%, respectively.
Conclusion: QFT-GIT is a simple, sensitive, and specific method for the diagnosis of clinically highly suspected TB fistula.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - Shukla HS / 1988 / Tubercular fistula in ano / Br J Surg 75 : 38 ~ 39
2. [학술지(정기간행물)] - Mazurek GH / 2005 / Guideline for using the QuantiFERON-TB gold test for detecting Mycobacterium tuberculosis infection, United States / MMWR Morb Mortal Wkly Rep 54 (RR-15) : 49 ~ 55
3. [학술지(정기간행물)] - Mori T / 2004 / Specific detection of tuberculosis infection: an interferon-gamma-based assay using new antigen / Am J Respir Crit Care Med 170 : 59 ~ 64
4. [학술지(정기간행물)] - Brock I / 2004 / Comparision of tuberculin skin test and new specific blood test in tuberculosis contacts / Am J Respir Crit Care Med 170 : 65 ~ 69
5. [인터넷자원] - WHO / / Treatment of tuberculosis: guidelines for national programmes. 3rd ed
2. [학술지(정기간행물)] - Mazurek GH / 2005 / Guideline for using the QuantiFERON-TB gold test for detecting Mycobacterium tuberculosis infection, United States / MMWR Morb Mortal Wkly Rep 54 (RR-15) : 49 ~ 55
3. [학술지(정기간행물)] - Mori T / 2004 / Specific detection of tuberculosis infection: an interferon-gamma-based assay using new antigen / Am J Respir Crit Care Med 170 : 59 ~ 64
4. [학술지(정기간행물)] - Brock I / 2004 / Comparision of tuberculin skin test and new specific blood test in tuberculosis contacts / Am J Respir Crit Care Med 170 : 65 ~ 69
5. [인터넷자원] - WHO / / Treatment of tuberculosis: guidelines for national programmes. 3rd ed
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