지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 182 - 188 (7page)
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Purpose: Accurate prediction of lymph node (LN) status is of crucial importance for appropriate treatment planning in early gastric cancer (EGC). Matrix metalloproteinases (MMPs) have been shown to be involved in the pathogenesis of tumor progression and metastasis in gastric carcinoma. In this study, we investigated the association between MMPs expressions and LN metastasis in EGC.
Methods: Thirty-four LN positive and 80 LN negative pT1 tumors were immunohistochemically analyzed for MMP-2, MMP-7, and MMP-9 expression. The relation of MMPs expressions to LN metastasis was analyzed in the univariate and multivariate model.
Results: There were 73 men and 41 women with a mean age of 60 years. Among the pathologic characteristics, larger tumor size, submucosal invasion and lymphatic invasion were factors that are significantly associated with LN metastasis in pT1 tumors. Immunohistochemistry showed significantly higher MMP-7 expression (82.4% vs. 54.4%, P=0.005) in LN positive tumors, whereas MMP-9 (85.3% in LN positive vs. 67.5% in LN negative) and MMP-2 (70.6% in LN positive vs. 57.5% in LN negative) expression did not reach statistical significance. Multivariate analysis revealed that MMP-7 expression (OR 4.915, 95% CI 1.375∼17.573) is an independent predictor of LN metastasis in EGCs, along with lymphatic invasion by tumor cells (OR 10.337, 95% CI 2.785∼38.360).
Conclusion: Our study shows that MMP-7 expression is significantly associated with LN metastasis in EGC. MMP-7 expression can be used to predict LN status in EGCs in addition to other pathological parameters.
Methods: Thirty-four LN positive and 80 LN negative pT1 tumors were immunohistochemically analyzed for MMP-2, MMP-7, and MMP-9 expression. The relation of MMPs expressions to LN metastasis was analyzed in the univariate and multivariate model.
Results: There were 73 men and 41 women with a mean age of 60 years. Among the pathologic characteristics, larger tumor size, submucosal invasion and lymphatic invasion were factors that are significantly associated with LN metastasis in pT1 tumors. Immunohistochemistry showed significantly higher MMP-7 expression (82.4% vs. 54.4%, P=0.005) in LN positive tumors, whereas MMP-9 (85.3% in LN positive vs. 67.5% in LN negative) and MMP-2 (70.6% in LN positive vs. 57.5% in LN negative) expression did not reach statistical significance. Multivariate analysis revealed that MMP-7 expression (OR 4.915, 95% CI 1.375∼17.573) is an independent predictor of LN metastasis in EGCs, along with lymphatic invasion by tumor cells (OR 10.337, 95% CI 2.785∼38.360).
Conclusion: Our study shows that MMP-7 expression is significantly associated with LN metastasis in EGC. MMP-7 expression can be used to predict LN status in EGCs in addition to other pathological parameters.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Gotoda T / 2007 / Endoscopic resection of early gastric cancer / Gastric Cancer 10 : 1 ~ 11
2. [학술지(정기간행물)] - Kim JJ / 2007 / EMR for early gastric cancer in Korea: a multicenter retrospective study / GASTROINTEST ENDOSCOP 66 : 693 ~ 700
3. [학술지(정기간행물)] - Gotoda T / 2000 / Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers / Gastric Cancer 3 : 219 ~ 225
4. [학술지(정기간행물)] - Maeda K / 1996 / Association of tumor cell proliferation with lymph node metastasis in early gastric cancer / Oncology 53 : 1 ~ 5
5. [학술지(정기간행물)] - Takeno S / 2001 / Analysis of early (pT1) gastric cancer with submucosal invasion: surgical management and possibility to schedule less invasive surgery / Ann Surg Oncol 8 : 605 ~ 610
2. [학술지(정기간행물)] - Kim JJ / 2007 / EMR for early gastric cancer in Korea: a multicenter retrospective study / GASTROINTEST ENDOSCOP 66 : 693 ~ 700
3. [학술지(정기간행물)] - Gotoda T / 2000 / Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers / Gastric Cancer 3 : 219 ~ 225
4. [학술지(정기간행물)] - Maeda K / 1996 / Association of tumor cell proliferation with lymph node metastasis in early gastric cancer / Oncology 53 : 1 ~ 5
5. [학술지(정기간행물)] - Takeno S / 2001 / Analysis of early (pT1) gastric cancer with submucosal invasion: surgical management and possibility to schedule less invasive surgery / Ann Surg Oncol 8 : 605 ~ 610
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