지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.3
- 수록면
- 19 - 26 (8page)
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Pigs have increasingly become useful models for toxicological and pharmacological studies because of the similarities of their anatomical morphology and physiology to those of humans. This study was conducted to evaluate of the quality control level through hematological features of minipig. Thus, we analyzed whether there are differences in hematological parameters between male and female minipigs. There were no significant differences in the levels of erythrocytes, hematocrit, mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), leukocytes (WBC), and serum electrolytes between male and female minipigs. But, leukocytes were higher than reference range in both sexes (26.46±2.06 vs 11.6±5.4 for male; 23.58±3.36 vs 10.0±2.0 for female). In differential leukocyte counts, all leukocyte parameters were not significantly different between both sexes. But, neutrophils were higher than reference range in both sexes (60.65±13.92 vs 33.1±18.9 for male; 46.84±12.80 vs 15.4±5.6 for female). In serum biochemical analysis, all biochemical parameters were not significantly different between male and female minipigs. However, aspartate aminotransferase (AST) and alkaline phosphatase (ALT) were higher than reference range, while alanine aminotransferase (ALP) was lower than reference range. In urine analysis, pH of male and female were 8.3±1.0 and 6.4±1.6, showing higher value in male minipig. These data indicate that quality control of minipig must take precedence in order to toxicological and pharmacological studies.
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UCI(KEPA) : I410-ECN-0101-2013-528-002902774