지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.3
- 수록면
- 69 - 73 (5page)
이용수
초록· 키워드
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The purpose of this study was to evaluate the potential of naturally occurring aldose reductase (AR) inhibitors from white-color natural products (Aruncus dioicus var. kamtschaticus, Chionanthus retusa, Cosmos bipinnatus, Hibiscus syriacus, Hydrangea paniculata, Magnolia denudata, Prunus padus, Robinia pseudo-accacia, Rhododendron mucronulatum for. albiflorum, Spiraea blumei, and Spiraea prunifolia var. simpliciflora). The MeOH extract of white-color natural products were tested on rat lens AR inhibition in vitro. Among them, the MeOH extract of R. mucronulatum for. albiflorum showed highest inhibition on AR (IC<SUB>50</SUB> value, 1.07 ㎍/ml). These results suggested that R. mucronulatum for. albiflorum, a white-color natural product, could be a useful resource in the development of a novel AR inhibitory agent against diabetic complications.
목차
Abstract
Ⅰ. Introduction
Ⅱ. Materials and methods
Ⅲ. Results and discussion
References
참고문헌 (29)
참고문헌 신청
안봉전 / 2005 / 진달래꽃(Rhododendron mucronulatum Turczaninow) 추출물의항산화, 항암 효과 및 tyrosinase 저해활성 / Journal of the Korean Society for Applied Biological Chemistry 48(3):280~284
Andrew GM / 2008 / QSAR prediction of inhibition of aldose reductase for flavonoids / Bioorg. Med. Chem 16:7470~7476
Beyer-Mears A / 1985 / Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor / Diabetes 34:15~21
Beyer-Mears A / 1984 / Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil / Diabetes 33:604~607
Chalk C / 2007 / Aldose reductase inhibitors for the treatment of diabetic polyneuropathy / Cochrane Database Syst. Rev 4:004572
Andrew GM / 2008 / QSAR prediction of inhibition of aldose reductase for flavonoids / Bioorg. Med. Chem 16:7470~7476
Beyer-Mears A / 1985 / Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor / Diabetes 34:15~21
Beyer-Mears A / 1984 / Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil / Diabetes 33:604~607
Chalk C / 2007 / Aldose reductase inhibitors for the treatment of diabetic polyneuropathy / Cochrane Database Syst. Rev 4:004572
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