지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.4
- 수록면
- 146 - 152 (7page)
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초록· 키워드
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Panax ginseng (PG) is a globally utilized medicinal herb. The medicinal effects of PG are primarily attributable to ginsenosides located in the root and leaf. The leaves of PG are known to be rich in various bioactive ginsenosides, and the therapeutic effects of ginseng extract and ginsenosides have been associated with immunomodulatory and anti-infl ammatory activities. We examined the effect of PG leaf extract and the isolated ginsenosides, on nuclear factor (NF)-κB transcriptional activity and target gene expression by applying a luciferase assay and reverse transcription polymerase chain reaction in tumor necrosis factor (TNF)-α-treated hepatocarcinoma HepG2 cells. Air-dried PG leaf extract inhibited TNF-α-induced NF-κB transcription activity and NF-κB-dependent cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) gene expression more effi ciently than the steamed extract. Of the 10 ginsenosides isolated from PG leaves, Rd and Km most signifi cantly inhibited activity in a dose-dependent manner, with IC50 values of 12.05±0.82 and 8.84±0.99 μM, respectively. Furthermore, the ginsenosides Rd and Km inhibited the TNF-α-induced expression levels of the COX-2 and iNOS gene in HepG2 cells. Air-dried leaf extracts and their chemical components, ginsenoside Rd and Km, are involved in the suppression of TNF-α-induced NF-κB activation and NF-κB-dependent iNOS and COX-2 gene expression. Consequently, air-dried leaf extract from PG, and the purifi ed ginsenosides, have therapeutic potential as anti-infl ammatory.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (32)
참고문헌 신청
1. [학술지(정기간행물)] - Berasain C / 2009 / Infl ammation and liver cancer : new molecular links / Ann N Y Acad Sci 1155 : 206 ~ 221
2. [학술지(정기간행물)] - Kawanishi S / 2006 / Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis / Biol Chem 387 : 365 ~ 372
3. [학술지(정기간행물)] - Yamashita T / 2010 / Molecular pathogenesis of hepatocellular carcinoma / Gan To Kagaku Ryoho 37 : 14 ~ 17
4. [학술지(정기간행물)] - Elsharkawy AM / 2007 / Nuclear factor-kappaB and the hepatic infl ammation-fi brosis-cancer axis / Hepatology 46 : 590 ~ 597
5. [학술지(정기간행물)] - Farinati F / 2010 / Oxidative stress and inducible nitric oxide synthase induction in carcinogenesis / Dig Dis 28 : 579 ~ 584
2. [학술지(정기간행물)] - Kawanishi S / 2006 / Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis / Biol Chem 387 : 365 ~ 372
3. [학술지(정기간행물)] - Yamashita T / 2010 / Molecular pathogenesis of hepatocellular carcinoma / Gan To Kagaku Ryoho 37 : 14 ~ 17
4. [학술지(정기간행물)] - Elsharkawy AM / 2007 / Nuclear factor-kappaB and the hepatic infl ammation-fi brosis-cancer axis / Hepatology 46 : 590 ~ 597
5. [학술지(정기간행물)] - Farinati F / 2010 / Oxidative stress and inducible nitric oxide synthase induction in carcinogenesis / Dig Dis 28 : 579 ~ 584
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