지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Acinetobacter infections are of great concern in clinical settings because of multi-drug resistance (MDR) and high mortality of the infected patients. The MDR Acinetobacter baumannii has emerged as a significant infectious agent in hospitals worldwide. The purpose of this study was to determine for molecular characterization of MDR A. baumannii clinical isolates obtained from the Wonju Christian Hospital in Gangwon province of Korea. A total of seventy nonduplicate A. baumannii isolates were collected from the Wonju Christian Hospital in Korea from March to April in 2011. All of the MDR A. baumannii isolates were encoded by blaOXA-23-like gene and all isolates with the blaOXA-23-like gene had the upstream element ISAba1 to promote increased gene expression and subsequent resistance to carbapenem. 16S rRNA methylase gene (armA) was detected in 44 clinical isolates which were resistant to amikacin, and phosphotransferase genes encoding aac(3)-Ia and aac(6")-Ib were the most prevalent. A combination of 16S rRNA methylase and aminoglycosidemodifying enzyme genes (armA, aac(3)-Ia, aac(6")-Ib, and aph(3")-Ia) were found in 31 isolates. The sequencing results for the quinolone resistance-determining region (QRDR) of gyrA and parC revealed the presence of Ser (TCA) 83 Leu (TTA) and Ser (TCG) 80 Leu (TTG) substitutions in the respective enzymes for all MDR. Molecular typing for MDR A. baumannii could be helpful in confirming the identification of a common source or cross-contamination. This is an important step in enabling epidemiological tracing of these strains.
목차
Acknowledgements
REFERENCES
참고문헌 (10)
참고문헌 신청
Cho YJ / 2009 / Genetic basis of resistance to aminoglycosides in Acinetobacter spp. and spread of armA in Acinetobacter baumannii sequence group 1 in Korean hospitals / DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 64:185~190
Dijkshoorn L / 1998 / Evaluation of amplified ribosomal DNA restriction analysis for identification of Acinetobacter genomic species / Syst Appl Microbiol 21:33~39
구선회 / 2010 / Genetic Basis of Multidrug-resistant Acinetobacter baumannii Clinical Isolates from Three University Hospitals in Chungcheong Province, Korea / Annals of Laboratory Medicine 30(5):498~506
Lee K / 2007 / Modified Hodge and EDTA-disk synergy tests to screen metallobeta- lactamase-producing strains of Pseudomonas and Acinetobacter species / Clin Microbiol Infect 7:88~91
Lee K / 2009 / Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea / International Journal Of Antimicrobial Agents 33(6):520~524
Dijkshoorn L / 1998 / Evaluation of amplified ribosomal DNA restriction analysis for identification of Acinetobacter genomic species / Syst Appl Microbiol 21:33~39
구선회 / 2010 / Genetic Basis of Multidrug-resistant Acinetobacter baumannii Clinical Isolates from Three University Hospitals in Chungcheong Province, Korea / Annals of Laboratory Medicine 30(5):498~506
Lee K / 2007 / Modified Hodge and EDTA-disk synergy tests to screen metallobeta- lactamase-producing strains of Pseudomonas and Acinetobacter species / Clin Microbiol Infect 7:88~91
Lee K / 2009 / Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea / International Journal Of Antimicrobial Agents 33(6):520~524
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UCI(KEPA) : I410-ECN-0101-2013-510-001744023