지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.3
- 수록면
- 57 - 65 (9page)
이용수
초록· 키워드
오류제보하기
In this study, the 4-week oral toxicity and anti-cancer activity of the hexane layer of Melia azedarach L. var. japonica Makino’s bark extract were investigated. We carried out a hollow fiber (HF) assay and 28-day repeated toxicity study to confirm the anti-cancer effect and safety of the hexane layer. The HF assay was carried out using an A549 human adenocarcinoma cell via intraperitoneal (IP) site with or without cisplatin. In the result, the 200 ㎎/㎏ b.w of hexane layer with 4 ㎎/㎏ b.w of cisplatin treated group, showed the highest cytotoxicity aginst A549 carcinoma cells. For the 28-day repeated toxicity study, 6 groups of 10 male and female mice were given by gavage 200, 100, or 50 ㎎/㎏ b.w hexane layer with or without 4 ㎎/㎏ b.w of cisplatin against body weight, and were then sacrificed for blood and tissue sampling. The subacute oral toxicity study in mice with doses of 200, 100, and 50 ㎎/㎏ b.w hexane layer showed no significant changes in body weight gain and general behavior. The cisplatin-treated group significantly decreased in body weight compared to the control group but regained weight with 100 and 200 ㎎/㎏ b.w of hexane layer. The biochemical analysis showed significant increase in several parameters (ALT, total billirubin, AST, creatinine, and BUN) in cisplatin-treated groups. However, in the group given a co-treatment of hexane layer (200 ㎎/㎏ b.w), levels of these parameters decreased. In hematological analysis, cisplatin induced the reduction of WBCs and neutrophils but co-treatment with hexane layer (100 and 200 ㎎/㎏ b.w) improved these toxicities caused by cisplatin. The histological profile of the livers showed eosinophilic cell foci in central vein and portal triad in cisplatin treated mice. These results show that hexane layer might have an anti-cancer activity and could improve the toxicity of cisplatin.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
Baguley, B.C / 1981 / Antitumour activity of substituted9-anilinoacridines-comparison of in vivo and in vitro testingsystems / Eur. J. Cancer 17:671~679
Boyd, M. R. / 1989 / Status of the NCI preclinical antitumor drug discovery screen / Principles and Practice of Oncology 3:1~12
Céspedes, C. L. / 2001 / Insect growth regulator and insecticidal activity of betadihydroagarofuransfrom Maytenus spp. (Celastraceae) / Z.Naturforsch C 56:603~613
Cha, S. M. / 1977 / Potential anticancer medicinal plants. A statistical evaluation of their frequencies of appearance in oriental medicine formularies / Kor. J. Pharmacogn 8:1~15
Ford, R. A. / 1988 / Monographs on fragrance raw materials / Food Chem. Toxicol 26:273~415
Boyd, M. R. / 1989 / Status of the NCI preclinical antitumor drug discovery screen / Principles and Practice of Oncology 3:1~12
Céspedes, C. L. / 2001 / Insect growth regulator and insecticidal activity of betadihydroagarofuransfrom Maytenus spp. (Celastraceae) / Z.Naturforsch C 56:603~613
Cha, S. M. / 1977 / Potential anticancer medicinal plants. A statistical evaluation of their frequencies of appearance in oriental medicine formularies / Kor. J. Pharmacogn 8:1~15
Ford, R. A. / 1988 / Monographs on fragrance raw materials / Food Chem. Toxicol 26:273~415
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2013-513-001730022