지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.3
- 수록면
- 51 - 56 (6page)
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초록· 키워드
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A novel synthetic hexapeptide (SFKLRY-NH₂) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). This study was carried out to investigate the irritation of the SFKLRY-NH₂ on the skin. The tests were performed on the basis of Korea Food and Drug Administration (KFDA) guidelines. In results, cell toxicity is not appeared for SFKLRYNH₂ in HaCaT cells and B16F10 cells. SFKLRY-NH₂ induced no skin irritation at low concentration (10 μM), mild irritation at high concentration (10mM). We consider that this result is helpful for saying about the safety of SFKLRY-NH₂ in clinical use.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (14)
참고문헌 신청
Aoshima, H. / 2009 / Safety evaluation of highly purified fullerenes (HPFs): based on screening of eye and skin damage / J. Toxicol. Sci 34:555~562
Aramburu, J. / 1999 / Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A / Science 285:2129~2133
류성호 / 200101 / Identification of novel chemoattractant peptides for human leukocytes / BLOOD 97(9):2854~2862
Baek, S. H. / 1996 / Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries / J. Biol. Chem 271:8170~8175
Bussolino, F. / 1997 / Molecular mechanisms of blood vessel formation / Trends. Biochem. Sci 22:251~256
Aramburu, J. / 1999 / Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A / Science 285:2129~2133
류성호 / 200101 / Identification of novel chemoattractant peptides for human leukocytes / BLOOD 97(9):2854~2862
Baek, S. H. / 1996 / Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries / J. Biol. Chem 271:8170~8175
Bussolino, F. / 1997 / Molecular mechanisms of blood vessel formation / Trends. Biochem. Sci 22:251~256
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UCI(KEPA) : I410-ECN-0101-2013-513-001730017