지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.3
- 수록면
- 39 - 46 (8page)
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초록· 키워드
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The effects of polarized-light therapy (PLT) on high-cholesterol diet (HCD)-induced hypercholesterolemia and atherosclerosis were investigated in comparison with that of lovastatin in rabbits. Hypercholesterolemia was induced by feeding male New Zealand white rabbits with 1% cholesterol in diet for 2 weeks and maintained with 0.5% cholesterol for 6 weeks, followed by normal diet for 2 weeks for recovery. Lovastatin (0.002% in diet) or daily 5-min or 20-min PLT on the outside surface of ears was started 2 weeks after induction of hypercholesterolemia. Hypercholesterolemic rabbits exhibited great increases in serum cholesterol and low-density lipoproteins (LDL) levels, and finally severe atheromatous plaques formation covering 57.5% of the arterial walls. Lovastatin markedly reduced both the cholesterol and LDL, but the reducing effect (47.5%) on atheroma formation was relatively low. By comparison, 5-min PLT preferentially decreased LDL, rather than cholesterol, and thereby potentially reduced the atheroma area to 42.2%. Notably, 20-min PLT was superior to lovastatin in reducing both the cholesterol and LDL levels as well as the atheromatous plaque formation (26.4%). In contrast to the increases in blood alanine transaminase and aspartate transaminase following lovastatin treatment, PLT did not cause hepatotoxicity. In addition, PLT decreased platelets and hematocrit level. The results indicate that PLT attenuates atherosclerosis not only by lowering blood cholesterol and LDL levels, but also by improving blood flow without adverse effects. Therefore, it is suggested that PLT could be a safe alternative therapy for the improvement of hypercholesterolemia and atherosclerosis.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (33)
참고문헌 신청
Moon SJ / 1996 / Nutritional problems in Korea / Kor J Nutr 29(4):371~380
Huh KB / 1990 / The present status of nutrition-related diseases and its countermeasures / Kor J Nutr 23(3):197~207
Lee HK / 1996 / Pattern of disease incidence and nutrition in Korea / Kor J Nutr 29(4):381~383
Lee YC / 1991 / Hypercholesterolemia in Korea and nutritional factors / Korean Soc Lipidol Atherosc 1(1):111~122
Spady DK / 1993 / Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids / Annu Rev Nutr 13:355~381
Huh KB / 1990 / The present status of nutrition-related diseases and its countermeasures / Kor J Nutr 23(3):197~207
Lee HK / 1996 / Pattern of disease incidence and nutrition in Korea / Kor J Nutr 29(4):381~383
Lee YC / 1991 / Hypercholesterolemia in Korea and nutritional factors / Korean Soc Lipidol Atherosc 1(1):111~122
Spady DK / 1993 / Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids / Annu Rev Nutr 13:355~381
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UCI(KEPA) : I410-ECN-0101-2013-510-001698926