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논문 기본 정보
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- 학술저널
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- 2012.3
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- 31 - 38 (8page)
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이 논문의 연구 히스토리 (2)
2012
Modulation of lipid metabolism by mixtures of protamine and chitooligosaccharide through pancreatic lipase inhibitory activity in a rat model
Nam-Hee Kang
,
Won Kyung Lee
,
Bo-Rim Yi
외 9명
Laboratory Animal Research
2012.03
학술저널
Modulation of lipid metabolism by mixtures of protamine and chitooligosaccaride through pancreatic lipase inhibitory activity in a rat model
Nam-Hee Kang
,
Won-Kyung Lee
,
Kyung-Chul Choi
한국실험동물학회 학술발표대회 논문집
2012.02
학술대회자료
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Overweight and obesity are usually related with high fat and calorie intake, and seriously causative of lifestyle-related diseases such as cardiovascular disorders, arteriosclerosis, and colon cancer. In this study, we propose a novel dietary therapy against overweight and obesity using mixtures of protamine and chitooligosaccharide (COS), which are known to interrupt the lipid metabolism in the body. Protamine is a dietary protein originated from salmon reproductive organ, and COS is an oligosaccharide made from chitin or chitosan by chemical or enzymatic hydrolysis. In the enzyme activity analysis in vitro, protamine and COS strongly suppressed the activity of pancreatic lipase, which is the primary enzyme for the digestion and absorption of lipids in the intestine. In in vivo animal test, the mixtures of protamine and COS significantly reduced the serum levels of triglyceride (TG), total cholesterol (T-CHO), and low density lipoprotein-cholesterol (LDLC) and inhibited the accumulation of lipids in liver tissue of Sprague Dawley (SD) rats fed high fat diets. On the other hand, they increased fecal TG and T-CHO contents. From these alterations in lipid metabolism, we verified that protamine and COS mixtures could effectively interrupt the digestion and absorption of dietary lipids in the body by inhibiting pancreatic lipase activity. In addition, protamine and COS mixtures increased the serum level of high density lipoprotein-cholesterol (HDLC), responsible for removing cholesterol from cells and protecting atherosclerosis, and therefore decreased the potential risks of cardiovascular diseases by lowering values of the atherogenic index (AI) and cardiac risk factor (CRF). Taken together, we suggest protamine and COS mixtures as a prominent dietary therapy for the prevention of overweight, obesity, and further cardiovascular diseases related with hyperlipidemia.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (25)
참고문헌 신청
Pokorski R / 2011 / Effect of increasing body weight on morbidity and mortality in South Korea / J Insur Med 42(2):78~84
배종면 / 2012 / Low Cholesterol is Associated with Mortality from Cardiovascular Diseases: A Dynamic Cohort Study in Korean Adults / Journal of Korean Medical Science 27(1):58~63
Ryota Hosomi / 2010 / Effect of dietary protamine on lipid metabolism in rats / Nutrition Research and Practice 4(6):462~469
Aspedon A / 1996 / The antibacterial action of protamine: evidence for disruption of cytoplasmic membrane energization in Salmonella typhimurium / Microbiology 142(Pt 12):3389~3397
Duarte-Vázquez MA / 2009 / Effect of protamine in obesity induced by high-fat diets in rats / Int J Obes (Lond) 33(6):687~692
배종면 / 2012 / Low Cholesterol is Associated with Mortality from Cardiovascular Diseases: A Dynamic Cohort Study in Korean Adults / Journal of Korean Medical Science 27(1):58~63
Ryota Hosomi / 2010 / Effect of dietary protamine on lipid metabolism in rats / Nutrition Research and Practice 4(6):462~469
Aspedon A / 1996 / The antibacterial action of protamine: evidence for disruption of cytoplasmic membrane energization in Salmonella typhimurium / Microbiology 142(Pt 12):3389~3397
Duarte-Vázquez MA / 2009 / Effect of protamine in obesity induced by high-fat diets in rats / Int J Obes (Lond) 33(6):687~692
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UCI(KEPA) : I410-ECN-0101-2013-510-001698911