지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.3
- 수록면
- 1 - 9 (9page)
이용수
초록· 키워드
오류제보하기
Exercise training can improve strength and lead to adaptations in the skeletal muscle and nervous systems. Skeletal muscles can develop into two types: fast and slow, depending on the expression pattern of myosin heavy chain (MHC) isoforms. Previous studies reported that exercise altered the distribution of muscle fiber types. It is not currently known what changes in the expression of caveolins and types of muscle fiber occur in response to the intensity of exercise. This study determined the changes in expression of caveolins and MHC type after forced exercise in muscular and non-muscular tissues in rats. A control (Con) group to which forced exercise was not applied and an exercise (Ex) group to which forced exercise was applied. Forced exercise, using a treadmill, was introduced at a speed of 25 m/min for 30 min, 3 times/day (07:00, 15:00, 23:00). Homogenized tissues were applied to extract of total RNA for further gene analysis. The expression of caveolin-3 and MHC2a in the gastrocnemius muscle of female rats significantly increased in the Ex group compared with the Con group (P<0.05). Furthermore, in the gastrocnemius muscle of male rats, the expression of MHC2x was significantly different between the two groups (P<0.05). There was an increased expression in caveolin-3 and a slightly decreased expression in TGFβ-1 in muscular tissues implicating caveolin-3 influences the expression of MHC isoforms and TGFβ-1 expression. Eventually, it implicates that caveolin-3 has positive regulatory function in muscle atrophy induced by neural dysfunction with spinal cord injury or stroke.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (42)
참고문헌 신청
Hood DA / 2007 / Exercise-induced mitochondrial biogenesis in skeletal muscle / Nutr Metab Cardiovasc Dis 17(5):332~337
Sharma HS / 1991 / Increased blood-brain barrier permeability following acute short-term swimming exercise in conscious normotensive young rats / Neuroscience Reserch 10(3):211~221
Medeiros A / 2008 / Effect of exercise training and carvedilol treatment on cardiac function and structure in mice with sympathetic hyperactivityinduced heart failure / Braz J Med Biol Res 41(9):812~817
Kovanen V / 1987 / Effects of age and life-time physical training on fiber composition of slow and fast skeletal muscle in rats / Pflugers Arch 408(6):543~551
Hammeren J / 1992 / Exercise training-induced alterations in skeletal muscle oxidative and antioxidant enzyme activity in senescent rats / Int J Sports Med 13(5):412~416
Sharma HS / 1991 / Increased blood-brain barrier permeability following acute short-term swimming exercise in conscious normotensive young rats / Neuroscience Reserch 10(3):211~221
Medeiros A / 2008 / Effect of exercise training and carvedilol treatment on cardiac function and structure in mice with sympathetic hyperactivityinduced heart failure / Braz J Med Biol Res 41(9):812~817
Kovanen V / 1987 / Effects of age and life-time physical training on fiber composition of slow and fast skeletal muscle in rats / Pflugers Arch 408(6):543~551
Hammeren J / 1992 / Exercise training-induced alterations in skeletal muscle oxidative and antioxidant enzyme activity in senescent rats / Int J Sports Med 13(5):412~416
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2013-510-001698875