지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Currently, resistance training is recommended as a behavioral intervention to enhance metabolic profile in diabetic patients. In the present study, we investigated the effect of resistance training on glucose transporter4(GLUT4) and monocarboxylate transporter(MCT) expression in skeletal muscle of rats with streptozotocin(STZ)-induced diabetes. Adult male Sprague-Dawley rats were randomly assigned to the following four groups: control group(n = 8), diabetic group(n = 8), diabetic and running group(n = 8), and diabetic and resistance group(n = 8). Diabetes was induced by a single injection of STZ(50 mg/kg body weight). Rats in the exercise groups were made to perform their respective exercise session four times per week for 12 weeks. Western blotting was performed to detect GLUT4 and MCT protein in skeletal muscle. Our data showed that GLUT4 and MCT protein levels was markedly decreased in the diabetic group when compared to the control group. However, both resistance and running training significantly increased GLUT4 and MCT protein in diabetic rats and the amount of these protein expression was similar between both trained groups. These results indicate that resistance training may be useful in alleviating metabolic impairment through the increase in glucose and lactate uptake in diabetic skeletal muscle.
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Abstract
1. 서론
2. 연구 방법
3. 결과
4. 논의
5. 결론
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참고문헌 (57)
참고문헌 신청
1. [학술지(정기간행물)] - Agurs-Collins, T. D. / 1997 / A randomized controlled trial of weight reduction and exercise for diabetes management in older African-American subjects / Diabetes Care 20 : 1503 ~ 1511
2. [학술지(정기간행물)] - Albright, A. / 2000 / American College of Sports Medicine position stand. Exercise and type 2 diabetes / Med. Sci. Sports Exerc. 32 : 1345 ~ 1360
3. [학술지(정기간행물)] - American Diabetes Association(ADA) / 2001 / Diabetes mellitus and exercise (Position Statement) / Diabetes Care 24 : 51 ~ 55
4. [학술지(정기간행물)] - Bonen, A. / 2001 / The expression of lactate transporters (MCT1 and MCT4) in heart and muscle / Eur. J. Appl. Physiol. 86 : 6 ~ 11
5. [학술지(정기간행물)] - Bonen, A. / 2000 / Lactate transporters (MCT proteins) in heart and skeletal muscles / Med. Sci. Sports Exerc. 32 : 778 ~ 789
2. [학술지(정기간행물)] - Albright, A. / 2000 / American College of Sports Medicine position stand. Exercise and type 2 diabetes / Med. Sci. Sports Exerc. 32 : 1345 ~ 1360
3. [학술지(정기간행물)] - American Diabetes Association(ADA) / 2001 / Diabetes mellitus and exercise (Position Statement) / Diabetes Care 24 : 51 ~ 55
4. [학술지(정기간행물)] - Bonen, A. / 2001 / The expression of lactate transporters (MCT1 and MCT4) in heart and muscle / Eur. J. Appl. Physiol. 86 : 6 ~ 11
5. [학술지(정기간행물)] - Bonen, A. / 2000 / Lactate transporters (MCT proteins) in heart and skeletal muscles / Med. Sci. Sports Exerc. 32 : 778 ~ 789
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UCI(KEPA) : I410-ECN-0101-2013-590-001579046