지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 55 - 60 (6page)
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초록· 키워드
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In a previous report, we demonstrated that ginsenoside Rc, one of major ginsenosides from Panax ginseng, enhances γ-aminobutyric acid (GABA) receptorA (GABA<SUB>A</SUB>)-mediated ion channel currents. However, little is known about the effects of ginsenoside metabolites on GABA<SUB>A</SUB> receptor channel activity. The present study investigated the effects of ginsenoside metabolites on human recombinant GABA<SUB>A</SUB> receptor (α₁β₁γ<SUB>2s</SUB>) channel activity expressed in Xenopus oocytes using a two-electrode voltage clamp technique. M4, a metabolite of protopanaxatriol ginsenosides, more potently inhibited the GABA-induced inward peak current (I<SUB>GABA</SUB>) than protopanaxadiol (PPD), a metabolite of PPD ginsenosides. The effect of M4 and PPD on I<SUB>GABA</SUB> was both concentration-dependent and reversible. The half-inhibitory concentration (IC??) values of M4 and PPD were 17.1±2.2 and 23.1±8.6 μM, respectively. The inhibition of I<SUB>GABA</SUB> by M4 and PPD was voltage-independent and non-competitive. This study implies that the regulation of GABA<SUB>A</SUB> receptor channel activity by ginsenoside metabolites differs from that of ginsenosides.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2013-524-001261143