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Hong-Geun Oh (휴벳) Hak-Yong Lee (휴벳) Min-Young Seo (휴벳) Young-Rye Kang (휴벳) Jung-Hoon Kim (휴벳) Jung-Woo Park (휴벳) Ok-Jin Kim (원광대학교) Hyang-Im Back (전북대학교병원) Sun-Young Kim (전북대학교병원) Mi-Ra Oh (전북대학교병원) Soo-Hyun Park (전북대학교병원) Min-Gul Kim (전북대학교병원) Ji-Young Jeon (전북대학교병원) Min-Ho Hwang (전북대학교병원) Sook-Jeong Shin (전북대학교병원) Soo-Wan Chae (전북대학교병원)
저널정보
한국실험동물학회 Laboratory Animal Research Laboratory Animal Research Vol.27 No.4
발행연도
2011.12
수록면
275 - 281 (7page)

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Constipation is one of the most common functional digestive complaints worldwide. We investigated the laxative effects of figs (Ficus carica L) in a beagle model of constipation induced by high protein diet and movement restriction. The experiments were consecutively conducted over 9 weeks divided into 3 periods of 3 weeks each. All 15 beagles were subjected to a non-treatment (control) period, a constipation induction period, and a fig paste treatment period. We administered fig paste (12 g/㎏ daily, by gavage) for 3 weeks following a 3-week period of constipation induction in dogs. Segmental colonic transit time (CTT) was measured by counting radiopaque markers (Kolomark) using a radiograph performed every 6 h after feeding Kolomark capsules, until capsules were no longer observed. Fig paste significantly increased fecal quantity in constipated dogs, and segmental CTT was also reduced following fig paste administration. There were no significant differences in feed intake, water intake, body weight, or blood test results, between the constipation and fig paste administration periods. Our results demonstrate that fig is an effective treatment for constipation in beagles. Specifically, stool weight increased and segmental CTT decreased. Fig pastes may be useful as a complementary medicine in humans suffering from chronic constipation.

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Materials and Methods
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UCI(KEPA) : I410-ECN-0101-2013-510-001228095