지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 689 - 693 (5page)
이용수
초록· 키워드
오류제보하기
The purpose of this study was to investigate the Cytochrome P450 (CYP2A6) gene as a candidate gene for the traits related with meat fatty acid composition traits in pigs. Porcine CYP2A6 polymorphisms were detected and PCR-RFLP was performed for genotyping of Korean native pig (n=14), Landrace (n=3), Duroc (n=3), Berkshire (n=3), Yorkshire (n=8) and F2 population composed of 202 individuals from an intercross between Korean Native pig and Yorkshire. PCR primer set amplified a 612 bp fragment of CYP2A6 and digestion of the PCR products was performed with the restriction enzymes SchI. The CYP2A6 SchI polymorphism was only found in the KNP breed. The genotype frequencies of TT, TC and CC genotypes were 0.36, 0.56 and 0.08 in the KNP respectively and the other pig breeds were fixed with CC genotype (Duroc, Landrace, Berkshire and Yorkshire). Statistical association between genotypes and fatty acid composition traits were tested in the Korean native pig and Yorkshire crossed F2 pigs. The CYP2A6 SchI polymorphism was associated with only fatty acid composition C20:3n3 level (cis11,14,17-Eicosatrienoic acid, p=0.0252). The "T" allele was associated with lower C20:3n3 level. Further study is required to validate the genotypic association and biological consequence of the CYP2A6 gene polymorphism in pigs.
목차
Abstract
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과 및 고찰
Ⅳ. 결론
감사의 글
참고문헌
참고문헌 (7)
참고문헌 신청
Ayajiki KH / 2003 / Mediation of arachidonic acid metabolite(s) produced by endothelial Cytochrome P-450 3A4 in monkey arterial relaxation / Hypertens. Res 26:237~243
Chen GR / 2008 / Regulation of CYP2A6 Protein Expression by Skatole , Indole, and Testicular Steroids in Primary Cultured Pig / Hepatocytes. Drug. Metab. Dispos 36:56~60
Kyung-Mi Choi / 2008 / Differential Expression of Cytochrome P450 Genes Regulate the Level of Adipose Arachidonic Acid in Sus Scrofa / ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 21(7):967~971
Chuang SS / 2004 / CYP2UI, a novel human thymus- and brain-specific Cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids / J. Biol. Chem 279:6305~6314
Kim TH / 200508 / Molecular characterization and chromosomal mapping of porcine adipose differentiation-related protein (ADRP) / JOURNAL OF ANIMAL BREEDING AND GENETICS 122:240~246
Chen GR / 2008 / Regulation of CYP2A6 Protein Expression by Skatole , Indole, and Testicular Steroids in Primary Cultured Pig / Hepatocytes. Drug. Metab. Dispos 36:56~60
Kyung-Mi Choi / 2008 / Differential Expression of Cytochrome P450 Genes Regulate the Level of Adipose Arachidonic Acid in Sus Scrofa / ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 21(7):967~971
Chuang SS / 2004 / CYP2UI, a novel human thymus- and brain-specific Cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids / J. Biol. Chem 279:6305~6314
Kim TH / 200508 / Molecular characterization and chromosomal mapping of porcine adipose differentiation-related protein (ADRP) / JOURNAL OF ANIMAL BREEDING AND GENETICS 122:240~246
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2013-480-001198057