지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 283 - 289 (7page)
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초록· 키워드
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Our previous study demonstrated that the Korean traditional medicine Gyeongshingangjeehwan (GGEx) activates AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor α (PPARα) critical for fatty acid oxidation in skeletal muscle and C2C12 skeletal muscle cells. Thus, we examined whether GGEx can reduce lipid accumulation in these cells and tissues. After obese and type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats were treated with GGEx, we studied the effects of GGEx on skeletal muscle lipid accumulation. The effects of GGEx and/or the AMPK inhibitor compound C on lipid accumulation and expression of AMPK and PPARα were measured in C2C12 skeletal muscle cells. Compared with lean Long-Evans Tokushima Otsuka rats, obese OLETF rats had increased triglyceride droplets. However, administration of GGEx to OLETF rats for 8 weeks significantly decreased triglyceride droplets in skeletal muscle. Consistent with the in vivo data, GGEx inhibited lipid accumulation, the degree of which was comparable to Wy14,643, the potent activator of PPARα. GGEx also increased skeletal muscle mRNA levels of AMPKα1, AMPKα2, and PPARα. However, compound C inhibited these effects in C2C12 cells. These results suggest that GGEx suppresses skeletal muscle lipid accumulation and this process may be mediated by AMPK and PPARα activation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
Acknowledgements
REFERENCES
참고문헌 (22)
참고문헌 신청
Collier CA / 2006 / Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle / Am J Physiol Regul Integr Comp Physiol 291:182~189
Consitt LA / 2009 / Intramuscular lipid metabolism, insulin action, and obesity / IUBMB Life 61:47~55
Dagenais GR / 1976 / Free fatty acid oxidation by forearm muscle at rest, and evidence for an intramuscular lipid pool in the human forearm / J Clin Invest 58:421~431
은재순 / 2006 / 補肺元湯이 면역반응에 미치는 영향 / 동의생리병리학회지 20(1):125~130
Fleming RM / 2008 / Safety of ephedra and related anorexic medications / Expert Opin Drug Saf 7:749~759
Consitt LA / 2009 / Intramuscular lipid metabolism, insulin action, and obesity / IUBMB Life 61:47~55
Dagenais GR / 1976 / Free fatty acid oxidation by forearm muscle at rest, and evidence for an intramuscular lipid pool in the human forearm / J Clin Invest 58:421~431
은재순 / 2006 / 補肺元湯이 면역반응에 미치는 영향 / 동의생리병리학회지 20(1):125~130
Fleming RM / 2008 / Safety of ephedra and related anorexic medications / Expert Opin Drug Saf 7:749~759
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UCI(KEPA) : I410-ECN-0101-2013-326-001453843