지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 241 - 246 (6page)
이용수
초록· 키워드
오류제보하기
To obtain soil microorganisms producing antimigratory activity which is important in controlling the metastasis of cancer cells, more than three hundreds of soil microbes were isolated from sixteen soil sources including Namsan mountain and designated as DGU1001-10338. At first, their antibiotic activities were examined by paper-disc method. More than 40 soil microbes produced compounds with antibiotic activity. Then, antimigratory activities of selected soil microorganisms were examined in a sphingosylphosphorylcholine-induced migration assay in PANC-1 cells. Six of 42 soil microorganisms having antibacterial activity also had more than 45% inhibitory activity on migration of PANC-1 cells. These results suggested that selected soil microorganisms were a useful starting point to find compounds for controlling metastasis of cancer cells.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (22)
참고문헌 신청
Beil, M. / 2003 / Sphingosylphosphorylcholine regulateskeratin network architecture and visco-elastic properties ofhuman cancer cells / Nat. Cell Biol 5:803~811
Dong Seok Cha / 2011 / Anti-metastatic Properties of the Leaves of Eriobotrya japonica / Archives of Pharmacal Research 34(3):425~436
Chaffer, C.L / 2011 / A perspective on cancercell metastasis / Science 331:1559~1564
Choi, H. / 2010 / Sphingosylphosphorylcholine down-regulatesfilaggrin gene transcription through NOX5-based NADPH oxidaseand cyclooxygenase-2 in human keratinocytes / Biochem.Pharmacol 80:95~103
Cross, S.E. / 2007 / Nanomechanicalanalysis of cells from cancer patients / Nat. Nanotechnol 2:780~783
Dong Seok Cha / 2011 / Anti-metastatic Properties of the Leaves of Eriobotrya japonica / Archives of Pharmacal Research 34(3):425~436
Chaffer, C.L / 2011 / A perspective on cancercell metastasis / Science 331:1559~1564
Choi, H. / 2010 / Sphingosylphosphorylcholine down-regulatesfilaggrin gene transcription through NOX5-based NADPH oxidaseand cyclooxygenase-2 in human keratinocytes / Biochem.Pharmacol 80:95~103
Cross, S.E. / 2007 / Nanomechanicalanalysis of cells from cancer patients / Nat. Nanotechnol 2:780~783
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UCI(KEPA) : I410-ECN-0101-2013-513-001112915