지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 217 - 224 (8page)
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초록· 키워드
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The object of this study was to evaluate the single oral dose toxicity of platycodin D, a saponin from the root of Platycodon grandiflorum in male and female mice. Platycodin D was administered to female and male mice as an oral dose of 2000, 1000, 500, 250 and 125 mg/kg (body wt.). Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after treatment, upon necropsy, organ weight and histopathology of 14 principle organs were examined. As the results, no platycodin D treatment related mortalities, clinical signs, changes on the body and organ weights, gross and histopathological observations against 14 principle organs were detected up to 2000 mg/kg in both female and male mice. Therefore, LDsub{50} (50% lethal dose) and approximate LD of playtcodin D after single oral treatment in female and male mice were considered over 2000 mg/kg ? the limited dosages recommended by KFDA Guidelines [2009-116, 2009], respectively.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGMENT
REFERENCES
참고문헌 (25)
참고문헌 신청
Banks,W.J / 1986 / Female reproductive system in Applied veterinaryhistology (Banks, W.J., Ed.) :506~526
Chung, J.W. / 2008 / Antiinflammatoryactivity of prosapogenin methyl ester of platycodinD via nuclear factor-kappaB pathway inhibition / Biol.Pharm. Bull 31:2114~2120
Choi, S.S. / 2002 / Antinociceptive mechanisms of platycodinD administered intracerebroventricularly in the mouse / Planta Med 68:794~798
Choi, S.S. / 2004 / Antinociceptive profiles of platycodin D in themouse / Am. J. Chin. Med 32:257~268
Dourish,C.T / 1987 / Effects of drugs on spontaneous motor activityin Experimental psychopharmacology (Greenshaw, A.J. andDourish, C.T., Eds.) :325~334
Chung, J.W. / 2008 / Antiinflammatoryactivity of prosapogenin methyl ester of platycodinD via nuclear factor-kappaB pathway inhibition / Biol.Pharm. Bull 31:2114~2120
Choi, S.S. / 2002 / Antinociceptive mechanisms of platycodinD administered intracerebroventricularly in the mouse / Planta Med 68:794~798
Choi, S.S. / 2004 / Antinociceptive profiles of platycodin D in themouse / Am. J. Chin. Med 32:257~268
Dourish,C.T / 1987 / Effects of drugs on spontaneous motor activityin Experimental psychopharmacology (Greenshaw, A.J. andDourish, C.T., Eds.) :325~334
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UCI(KEPA) : I410-ECN-0101-2013-513-001112884