지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 191 - 203 (13page)
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초록· 키워드
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There has been growing concern about the toxicity of phthalate esters. Phthalate esters are being used widely for the production of perfume, nail varnish, hairsprays and other personal/cosmetic uses. Recently, exposure to phthalates has been assessed by analyzing urine for their metabolites. The parent phthalate is rapidly metabolized to its monoester (the active metabolite) and also glucuronidated, then excreted. The objective of this study is to evaluate the toxicity of phthalic acid (PA), which is the final common metabolic form of phthalic acid esters (PAEs). The individual PA isomers are extensively employed in the synthesis of synthetic agents, for example isophthalic acid (IPA), and terephthalic acid (TPA), which have very broad applications in the preparation of phthalate ester plasticizers and components of polyester fiber, film and fabricated items. There is a broad potential for exposure by industrial workers during the manufacturing process and by the general public (via vehicle exhausts, consumer products, etc). This review suggests that PA shows in vitro and in vivo toxicity (mutagenicity, developmental toxicity, reproductive toxicity, etc.). In addition, PA seems to be a useful biomarker for multiple exposure to PAEs in humans.
목차
INTRODUCTION
TOXICOLOGICAL CHARACTERISTICS OF PAs
EFFECTS ON HUMANS
DISCUSSION
REFERENCES
참고문헌 (101)
참고문헌 신청
Agarwal, D.K. / 1985 / Mutagenicity evaluation of phthalic acid esters andmetabolites in Salmonella typhimurium cultures / J. Toxicol.Environ. Health 16:61~69
Albro, P.W. / 1973 / Metabolism ofdiethylhexyl phthalate by rats. Isolation and characterization ofthe urinary metabolites / J. Chromatogr 76:321~330
Albro, P.W / 1973 / Enzymatic hydrolysis of di-(2-ethylhexyl) phthalate by lipases / Biochim. Biophys. Acta.Biochim 306:380~390
Albro, P.W / 1974 / Identification of the metabolitesof simple phthalate diesters in rat urine / J. Chromatogr 94:209~218
Albro, P.W. / 1984 / Determination of total phthalate in urine by gas chromatography / Anal. Chem 56:247~250
Albro, P.W. / 1973 / Metabolism ofdiethylhexyl phthalate by rats. Isolation and characterization ofthe urinary metabolites / J. Chromatogr 76:321~330
Albro, P.W / 1973 / Enzymatic hydrolysis of di-(2-ethylhexyl) phthalate by lipases / Biochim. Biophys. Acta.Biochim 306:380~390
Albro, P.W / 1974 / Identification of the metabolitesof simple phthalate diesters in rat urine / J. Chromatogr 94:209~218
Albro, P.W. / 1984 / Determination of total phthalate in urine by gas chromatography / Anal. Chem 56:247~250
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