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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.10
- 수록면
- 1,284 - 1,287 (4page)
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초록· 키워드
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Tumor necrosis factor (TNF)-α is chronically elevated in adipose tissues of obese rodents and humans. Increased levels of TNF-α have been implicated in both the induction of atherogenic adipokines, such as plasminogen activator inhibitor (PAI)-1, and the inhibition of the anti-atherogenic adipokine, adiponectin. In this study, we investigated the effects of transstilbene, piceatannol, rhaponticin, and piceid on the TNF-α-induced atherogenic changes of adipokines in 3T3-L1 cells. Exposure to TNF-α for 24 hr increased PAI-1 secretion and decreased adiponectin secretion. Among stilbenoids, piceatannol significantly inhibited the increased secretion of PAI-1 induced by TNF-α. Adiponectin secretion decreased by TNF-α was recovered after trans-stilbene and rhaponticin treatments. Our results showed that stilbenoids exerted different effects on TNF-α-induced changes in adipokines secretion in 3T3-L1 adipocytes according to their structural characteristics.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (37)
참고문헌 신청
1. [학술지(정기간행물)] - Bavaresco L / 1999 / Stilbene compounds: From the grapevine to wine / Drug Exp. Clin. Res. 25 : 57 ~ 63
2. [학술지(정기간행물)] - Arichi H / 1982 / Effects of stilbene components of the roots of Polygonum cuspidatum Sieb. et Zucc. on lipid metabolism / Chem. Pharm. Bull. 30 : 1766 ~ 1770
3. [학술지(정기간행물)] - Picard F / 2004 / Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma / Nature 429 : 771 ~ 776
4. [학술지(정기간행물)] - Yamamoto H / 2007 / Sirtuin functions in health and disease / Mol. Endocrinol. 21 : 1745 ~ 755
5. [학술지(정기간행물)] - Thakkar K / 1993 / Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol / J. Med. Chem. 36 : 2950 ~ 2955
2. [학술지(정기간행물)] - Arichi H / 1982 / Effects of stilbene components of the roots of Polygonum cuspidatum Sieb. et Zucc. on lipid metabolism / Chem. Pharm. Bull. 30 : 1766 ~ 1770
3. [학술지(정기간행물)] - Picard F / 2004 / Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma / Nature 429 : 771 ~ 776
4. [학술지(정기간행물)] - Yamamoto H / 2007 / Sirtuin functions in health and disease / Mol. Endocrinol. 21 : 1745 ~ 755
5. [학술지(정기간행물)] - Thakkar K / 1993 / Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol / J. Med. Chem. 36 : 2950 ~ 2955
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UCI(KEPA) : I410-ECN-0101-2013-573-000874507