Effective elastic constants of bone-like biocomposites are investigated numerically. The bone-like materials are composed of strong layers and weak layers, and hierarchically structured. The unit cell model is employed to obtain the effective elastic constants. The effective anisotropic elastic constants of bone-like composites are obtained by using the potential energy method and finite element analysis. The effects of the Poisson’s ratio, elastic modulus, hierarchical level, volume fraction and aspect ratio of the strong layer composed of the composites on the effective elastic constants are discussed.