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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 267 - 271 (5page)
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초록· 키워드
오류제보하기
P19 cells are pluripotent embryonal carcinoma cells and can be differentiated into neuronal cell type by treatment with retinoic acid (RA) and aggregation culture. Cannabinoids are the active components of Cannabis sativa and they have diverse pharmacologic activities, such as pain control, anti-inflammatory effects, neuro-protection effects and tumor regression. Cannabinoids also involved in neuronal proliferation, migration, differentiation and survival in developing brain. Here, we studied the role of cannabinoids on neuronal differentiation of P19 cells. Treatment with cannabinoids increased the neuronal differentiation induced by RA and also promoted transcriptional activity of neurogenin 1, key transcription factor for neuronal differentiation of P19 cells. These results suggest that the cannabinoids can accelerate neuronal differentiation of P19 cells.
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REFERENCES
참고문헌 (25)
참고문헌 신청
1. [학술지(정기간행물)] - Aguado T / 2005 / The endocannabinoid system drives neural progenitor proliferation / FASEB J 19 : 1704 ~ 1706
2. [학술지(정기간행물)] - Bain G / 1994 / From embryonal carcinoma cells to neurons: the P19 pathway / Bioessays 16 : 343 ~ 348
3. [학술지(정기간행물)] - Bisogno T / 2005 / The endocannabinoid signalling system: biochemical aspects / Pharmacol Biochem Behav 81 : 224 ~ 238
4. [학술지(정기간행물)] - Cho JH / 2001 / Overexpression of BETA2/NeuroD induces neurite outgrowth in F11 neuroblastoma cells / J Neurochem 77 : 103 ~ 109
5. [학술지(정기간행물)] - Ghil S / 2006 / Compartmentalization of protein kinase A signaling by the heterotrimeric G protein Go / Proc Natl Acad Sci U S A 103 : 19158 ~ 19163
2. [학술지(정기간행물)] - Bain G / 1994 / From embryonal carcinoma cells to neurons: the P19 pathway / Bioessays 16 : 343 ~ 348
3. [학술지(정기간행물)] - Bisogno T / 2005 / The endocannabinoid signalling system: biochemical aspects / Pharmacol Biochem Behav 81 : 224 ~ 238
4. [학술지(정기간행물)] - Cho JH / 2001 / Overexpression of BETA2/NeuroD induces neurite outgrowth in F11 neuroblastoma cells / J Neurochem 77 : 103 ~ 109
5. [학술지(정기간행물)] - Ghil S / 2006 / Compartmentalization of protein kinase A signaling by the heterotrimeric G protein Go / Proc Natl Acad Sci U S A 103 : 19158 ~ 19163
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UCI(KEPA) : I410-ECN-0101-2013-510-000796509