지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 231 - 238 (8page)
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초록· 키워드
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During pregnancy, stress induces maternal glucocorticoid secretion, which in turn is known to affect structural malformation, retardation of growth, reduced birth weight of the fetus. As Hox genes are master transcription factors which fulfill critical roles in embryonic development, we aimed to explore the possibility that alterations of the Hox gene expression might be involved in stress-induced malformation. The pregnant mice were injected with dexamethasone at a dose of 1 mg/kg or 10 mg/kg on day 7.5, 8.5 and 9.5 p.c. (post coitum), as well as saline as control. Embryos of E11.5 and E18.5 were obtained by sacrificing pregnant animals. Weight and crown-rump length (CRL) were measured. RT-PCR was performed to examine the Hox gene expression levels. Embryos given dexamethasone at day 7.5~9.5 p.c. had small CRL and weighed less both in E11.5 and E18.5. The percentage of embryos showing abnormalities was high in groups received high dose of dexamethasone. To define the molecular basis for abnormal embryonic development, we analyzed the Hox gene expression pattern and found that many Hox genes display altered expression. Effects of prenatal dexamethasone treatment on embryonic development might be associated with the aberrant Hox gene expression.
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고찰
REFERENCES
참고문헌 (41)
참고문헌 신청
Akam M / 1989 / Hox and HOM: Homologous gene clusters in insects and vertebrates / Cell 57:347~349
Aubin J / 1999 / Loss of Hoxa5 gene function in mice perturbs intestinal maturation / Am J Physiol 277:965~973
Awgulewitsch A / 2003 / Hox in hair growth and development / Naturwissenschaften 90:193~211
Baisden B / 2007 / Antenatal dexamethasone treatment leads to changes in gene expression in a murine late placenta / Placenta 28:1082~1090
Barker DJ / 1993 / Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (Syndrome X): relation to reduced fetal growth / Diabetologia 36:62~67
Aubin J / 1999 / Loss of Hoxa5 gene function in mice perturbs intestinal maturation / Am J Physiol 277:965~973
Awgulewitsch A / 2003 / Hox in hair growth and development / Naturwissenschaften 90:193~211
Baisden B / 2007 / Antenatal dexamethasone treatment leads to changes in gene expression in a murine late placenta / Placenta 28:1082~1090
Barker DJ / 1993 / Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (Syndrome X): relation to reduced fetal growth / Diabetologia 36:62~67
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UCI(KEPA) : I410-ECN-0101-2013-510-000796458