지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 225 - 230 (6page)
이용수
초록· 키워드
오류제보하기
Indirubin is the active ingredient of Danggui Longhui Wan, a mixture of plants that is used in traditional Chinese medicine to treat chronic diseases. In this study we investigated the anti-inflammatory effects of an indirubin derivative, indirubin-3'-monoxime-5-sulphonic acid (I3M-5S, C<sub>16</sub>H<sub>11</sub>N<sub>3</sub>O<sub>5</sub>S). We found that I3M-5S inhibits the production of various inflammatory mediators such as nitric oxide (NO) and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) as well as inflammatory cytokines, tumor necrosis factor-α and interleukin-6 in lipopolysaccharide (LPS) stimulated murine macrophage, RAW264.7 cells. In addition, the expression of inducible nitric oxide synthase and cyclooxygenase-2, which are essential enzymes to produce NO and PGE<sub>2</sub>, respectively, was blocked by I3M-5S treatment in LPS-stimulated RAW264.7 cells. Present data suggest that I3M-5S exhibits potent anti-inflammatory activity in cultured macrophages and merit further study as potential therapeutic agents for inflammatory disorders.
목차
서론
재료 및 방법
결과 및 고찰
REFERENCES
참고문헌 (18)
참고문헌 신청
Baldwin AS Jr / 1996 / The NF-κB and IκB proteins: new discoveries and insights / Annu Rev Immunol 14:649~683
Botting RM / 2006 / Inhibitors of cyclooxygenases: mechanisms, selectivity and uses / J Physiol Pharmacol 5:113~124
Bryniarski K / 2003 / Modulation of macrophage activity by proteolytic enzymes. Differential regulation of IL-6 and reactive oxygen intermediates (ROIs) synthesis as a possible homeostatic mechanism in the control of inflammation / Inflammation 27:333~340
Butchar JP / 2006 / Negative regulators of toll-like receptor 4-mediated macrophage inflammatory response / Curr Pharm Des 12:4143~4153
Christie RM / 2007 / Why is indigo blue / Biotech Histochem 82:51~56
Botting RM / 2006 / Inhibitors of cyclooxygenases: mechanisms, selectivity and uses / J Physiol Pharmacol 5:113~124
Bryniarski K / 2003 / Modulation of macrophage activity by proteolytic enzymes. Differential regulation of IL-6 and reactive oxygen intermediates (ROIs) synthesis as a possible homeostatic mechanism in the control of inflammation / Inflammation 27:333~340
Butchar JP / 2006 / Negative regulators of toll-like receptor 4-mediated macrophage inflammatory response / Curr Pharm Des 12:4143~4153
Christie RM / 2007 / Why is indigo blue / Biotech Histochem 82:51~56
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UCI(KEPA) : I410-ECN-0101-2013-510-000796443