지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 217 - 223 (7page)
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초록· 키워드
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β-sitosterol glucoside exists in a variety of plants and have anti-tumor, anti-microbial, and immunomodulatory activities. Mast cells and eosinophils play important roles in a variety of inflammatory diseases, specifically asthma and atopic dermatitis. In the present study, we used lactose-β-sitosterol (L-BS) and investigated the effect of L-BS on inflammatory responses of the human mast cell line, HMC-1 and the human eosinophilic leukemia cell line, EoL-1. In HMC-1 cells, L-BS significantly inhibited cell migration in response to stem cell factor without cytotoxicity. However, the mRNA expression of CC chemokine receptors (CCRs), including CCR1-5, were not altered after L-BS treatment in HMC-1 cells. LPS-induced IL-4 production was also suppressed by L-BS in a dose-dependent manner. In EoL-1 cells, the concentration ranging from 0.1 μM to 10 μM of L-BS had no cytotoxicity and had no effect on mRNA expression of major protein-mediators derived from activated eosinophils. However, 100 μM of L-BS induced the apoptosis of EoL-1 cells in a time-dependent manner. This finding indicates the possibility of L-BS as a potential therapeutic molecule in inflammatory diseases and may contribute to the need to improve current therapeutic drugs.
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재료 및 방법
결과
고찰
REFERENCES
참고문헌 (22)
참고문헌 신청
Barnes PJ / 1998 / Inflammatory mediators of asthma: an update / Pharmacol Rev 50:515~596
Bisset LR / 2005 / Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective / Current Opinion Pulmonary Medicine 11:35~42
Bouic PJ / 1996 / Beta-Sitosterol and beta-sitosterol glucoside stimulate human peripheral blood lymphocyte proliferation: implications for their use as an immunomodulatory vitamin combination / Int J Immunopharmacol 18:693~700
Bouic PJ / 1999 / Plant sterols and sterolins: a reviewof their immune-modulating properties / Altern Med Rev 4:170~177
최은진 / 2011 / CCR Expression of Bronchoalveolar Lavage Fluid (BALF) Neutrophils and Chemotactic Activity of BALF / 대한의생명과학회지 17(1):89~93
Bisset LR / 2005 / Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective / Current Opinion Pulmonary Medicine 11:35~42
Bouic PJ / 1996 / Beta-Sitosterol and beta-sitosterol glucoside stimulate human peripheral blood lymphocyte proliferation: implications for their use as an immunomodulatory vitamin combination / Int J Immunopharmacol 18:693~700
Bouic PJ / 1999 / Plant sterols and sterolins: a reviewof their immune-modulating properties / Altern Med Rev 4:170~177
최은진 / 2011 / CCR Expression of Bronchoalveolar Lavage Fluid (BALF) Neutrophils and Chemotactic Activity of BALF / 대한의생명과학회지 17(1):89~93
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UCI(KEPA) : I410-ECN-0101-2013-510-000796438