지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 211 - 216 (6page)
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초록· 키워드
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The chitosan-coated liposomes (chitosomes) were designed to improve the stability in the gastrointestinal (GI) tract and to enhance the efficacy for oral drug delivery of liposomes. The phosphatic acid (PA)-incorporated anionic liposomes were surface-coated with water soluble chitosan (WSC) by electro-ionic interaction. The shape of the chitosomes observed by transmission electron microscopy (TEM) was spherical in all the formulations and the coating layer by WSC could be founded through TEM images. The mean size and the zeta potential values of the chitosomes increased significantly with depending on the content of WSC added for coating the liposomes. The stability of the chitosomes in the GI tract was confirmed through the change of relative turbidity of the liposomal suspension. The plain liposomes (plasomes) suspension without adding WSC clearly showed the change of relatively turbidity in simulated gastric fluid (SGF), while the change degree of turbidity of the chitosomes in the SGF decreased as increasing of WSC content added for coating liposome. In the 5-CF release study from the plasomes and chitosomes, the plasomes released >90% of the initial 5-CF content at 4 h of release measurement. In contrast, the chitosomes released below 40% of initial content of 5-CF. In conclusion, these results indicate that the chitosomes can be used as a potential carrier for effective oral drug delivery.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Barea MJ / 2010 / Evaluation of liposomes coated with a pH responsive polymer / Int J Pharm 402 : 89 ~ 94
2. [학술지(정기간행물)] - Cao J / 2009 / N-trimethyl chitosan-coated multivesicular liposomes for oxymatrine oral delivery / Drug Dev Ind Pharm 35 : 1339 ~ 1347
3. [학술지(정기간행물)] - Childers NK / 1990 / Ultrastructural study of liposome uptake by M cell of rat Peyer's patch: an oral vaccine system for delivery of purified antigen / Reg Immunol 3 : 289 ~ 296
4. [학술지(정기간행물)] - Demarger-Andre S / 1993 / Chitosan behaviours in a dispersion of undecylenic acid / Carbohyd Polym 22 : 117 ~ 126
5. [학술지(정기간행물)] - Dodane V / 1999 / Effect of chitosan on epithelial permeability and structure / Int J Pharm 182 : 21 ~ 32
2. [학술지(정기간행물)] - Cao J / 2009 / N-trimethyl chitosan-coated multivesicular liposomes for oxymatrine oral delivery / Drug Dev Ind Pharm 35 : 1339 ~ 1347
3. [학술지(정기간행물)] - Childers NK / 1990 / Ultrastructural study of liposome uptake by M cell of rat Peyer's patch: an oral vaccine system for delivery of purified antigen / Reg Immunol 3 : 289 ~ 296
4. [학술지(정기간행물)] - Demarger-Andre S / 1993 / Chitosan behaviours in a dispersion of undecylenic acid / Carbohyd Polym 22 : 117 ~ 126
5. [학술지(정기간행물)] - Dodane V / 1999 / Effect of chitosan on epithelial permeability and structure / Int J Pharm 182 : 21 ~ 32
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UCI(KEPA) : I410-ECN-0101-2013-510-000796423