지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 251 - 254 (4page)
이용수
초록· 키워드
오류제보하기
An abnormal swelling was identified in the distal portion of the right femur in a 1-year-old non-obese diabetic (NOD) mouse. Grossly, a large mass of the distal femur was observed in the right femur. Lesions were poorly marginated, associated with destruction of the cancellous and cortical elements of the bone, and showed ossification within the soft tissue component. Histologically, the tumor was identified as a poorly differentiated sarcoma. Histopathologic examination of the bone masses revealed invasive proliferation of poorly differentiated neoplastic mesenchymal cells forming streams, bundles, and nests, which resulted in destruction of normal bone. Neoplastic cells exhibited random variation in cellular appearance and arrangement, as well as matrix composition and abundance. Haphazard and often intermingling patterns of osteogenic, chondroblastic, lipoblastic, and angiogenic tissues were present. Larger areas of neoplastic bone and hyaline cartilage contained multiple large areas of hemorrhage and necrosis bordered by neoplastic cells. The mass was diagnosed as an osteosarcoma. To our knowledge, this is the first spontaneous osteosarcoma in an NOD mouse.
목차
Acknowledgments
References
참고문헌 (23)
참고문헌 신청
Huvos A / 1991 / Bone Tumors: Diagnosis, Treatment, Prognosis / WB Saunders :784
Sissons HA / 1976 / The WHO classification of bone tumors / Recent Results Cancer Res 54(1):104~108
McKenna RJ / 1966 / Sarcomas of the osteogenic series (osteosarcoma, chondrosarcoma, parosteal osteogenic sarcoma, and sarcomata arising in abnormal bone): an analysis of 552 cases / J Bone Joint Surg Am 48(1):1~26
Gurney JG / 1999 / Malignant bone tumors. In: Cancer Incidence and Survival Among Children and Adolescents: United States SEER Program 1975-1995 / National Cancer Institute :99~110
Smith MA / 1999 / Cancer in adolescents 15 to 19 years old. In: Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995 / National Cancer Institute :111~200
Sissons HA / 1976 / The WHO classification of bone tumors / Recent Results Cancer Res 54(1):104~108
McKenna RJ / 1966 / Sarcomas of the osteogenic series (osteosarcoma, chondrosarcoma, parosteal osteogenic sarcoma, and sarcomata arising in abnormal bone): an analysis of 552 cases / J Bone Joint Surg Am 48(1):1~26
Gurney JG / 1999 / Malignant bone tumors. In: Cancer Incidence and Survival Among Children and Adolescents: United States SEER Program 1975-1995 / National Cancer Institute :99~110
Smith MA / 1999 / Cancer in adolescents 15 to 19 years old. In: Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995 / National Cancer Institute :111~200
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UCI(KEPA) : I410-ECN-0101-2013-510-000764490