지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 167 - 172 (6page)
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초록· 키워드
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We demonstrate that glycoprotein isolated from Dioscorea batatas (GDB) activates macrophage function. Analysis of the infiltration of macrophages into peritoneal cavity showed GDB treatment significantly increased the recruitment of macrophages into the peritoneal cavity. In order to further confirm and investigate the mechanism of GDB on macrophage activation, we analyzed the effects of GDB on the cytokine expression including IL-1β, TNF-α, and IL-6 in mouse peritoneal macrophages. GDB increased the expression of IL-1β, TNF-α, and IL-6. Cytokine induction by GDB was further confirmed by RT-PCR and ELISA in mouse macrophage cell line, RAW264.7 cells. Treatment of RAW264.7 cells with GDB produced strong induction of NF-κB DNA binding and MAPK phosphorylation, markers for macrophage activation and important factors for cytokine gene expression. Collectively, this series of experiments indicates that GDB stimulates macrophage activation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (26)
참고문헌 신청
Billack,B / 2006 / Macrophage activation: role of toll-like receptors,nitric oxide, and nuclear factor kappa B / Am. J. Pharm.Educ 70:102
Chen, H. / 2003 / Effects ofTaiwanese yam (Dioscorea japonica Thunb var. pseudojaponicaYamamoto) on upper gut function and lipid metabolism inBalb/c mice / Nutrition 19:646~651
Gaidamashvili, M. / 2004 / Characterization of the yam tuberstorage proteins from Dioscorea batatas exhibiting unique lectinactivities / J. Biol. Chem 279:26028~26035
Goyert, S.M. / 1988 / The CD14 monocyte differentiationantigen maps to a region encoding growth factors andreceptors / Science 239:497~500
Green, L.C. / 1982 / Analysis of nitrate,nitrite, and [15N]nitrate in biological fluids / Anal. Biochem 126:131~138
Chen, H. / 2003 / Effects ofTaiwanese yam (Dioscorea japonica Thunb var. pseudojaponicaYamamoto) on upper gut function and lipid metabolism inBalb/c mice / Nutrition 19:646~651
Gaidamashvili, M. / 2004 / Characterization of the yam tuberstorage proteins from Dioscorea batatas exhibiting unique lectinactivities / J. Biol. Chem 279:26028~26035
Goyert, S.M. / 1988 / The CD14 monocyte differentiationantigen maps to a region encoding growth factors andreceptors / Science 239:497~500
Green, L.C. / 1982 / Analysis of nitrate,nitrite, and [15N]nitrate in biological fluids / Anal. Biochem 126:131~138
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UCI(KEPA) : I410-ECN-0101-2013-513-000310537