지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 113 - 122 (10page)
이용수
초록· 키워드
오류제보하기
Several studies have reported a relation between serum levels of uric acid and a wide variety of cardiovascular conditions. But, the relationship between serum levels of uric acid and coronary artery disease (CAD) is still controversial. The present study was retrospectively designed to investigate whether CAD can be stratified by the level of uric acid and there are the relationships between preoperative levels of uric acid and perioperative biochemical markers in fifty-adult patients that underwent coronary artery bypass grafting surgery (CABG) and twenty-normal subjects. They were divided into the control, the unstable angina (UA-group) and the myocardial infarction group (MI-group). In preoperative levels of uric acid, the MI-group was higher than control and the UA-group. The MI-group had significantly higher correlations than the UA-group between preoperative levels of uric acid and left ventricular ejection fraction, cardiac markers (creatine kinase, lactate dehydrogenase and brain natriuretic peptide), renal markers (blood urea nitrogen and creatinine) or total leukocyte levels. At postoperative periods, the MI-group had higher relationships of uric acid with aspartate aminotransferase, blood urea nitrogen or creatinine levels. Although there was not statistically significant, the UA-group tended to have higher correlation coefficients than the MI-group between preoperative levels of uric acid and intensive care unit-stay (ICU), or postoperative mechanical ventilation time. These results reflect that increased levels of serum uric acid may be a tool for the diagnosis of coronary heart disease and may be considered as a good predictor in assessing the cardiac and renal functions in patients with myocardial infarction or unstable angina at the preoperative period. However, further studies should be performed in a large patient population.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (40)
참고문헌 신청
Achar SA / 2005 / Diagnosis of acute coronary syndrome / Am Fam Physician 72:119~126
Alberto P / 2006 / Acute coronary syndromes: From the laboratory markers to the coronary vessels / Biomarker Insights 1:123~130
Anderson RJ / 1999 / Renal failure predisposes patients to adverse outcome after coronary artery bypass surgery / Kidney Int 55:1057~1062
Anker SD / 2003 / Uric acid and survival in chronic heart failure: Validation and application in metabolic, functional, and hemodynamic staging / Circulation 107:1991~1997
Baker JF / 2005 / Serum uric acid and cardiovascular disease: Recent developments, and where do they leave us / Am J Med 118:86~826
Alberto P / 2006 / Acute coronary syndromes: From the laboratory markers to the coronary vessels / Biomarker Insights 1:123~130
Anderson RJ / 1999 / Renal failure predisposes patients to adverse outcome after coronary artery bypass surgery / Kidney Int 55:1057~1062
Anker SD / 2003 / Uric acid and survival in chronic heart failure: Validation and application in metabolic, functional, and hemodynamic staging / Circulation 107:1991~1997
Baker JF / 2005 / Serum uric acid and cardiovascular disease: Recent developments, and where do they leave us / Am J Med 118:86~826
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UCI(KEPA) : I410-ECN-0101-2013-510-000412737