지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 171 - 176 (6page)
이용수
초록· 키워드
오류제보하기
Diabetic neuropathy is one of the most frequent and troublesome complications of diabetes. Although there has been a continuous increase in the incidence of diabetic neuropathy, treatments have yet to be found that effectively treat diabetic neuropathy. Neurotrophic factors are proteins that promote the survival of specific neuronal populations. They also play key roles in the regeneration of peripheral nervous system. Recent evidence from diabetic animal models and human diabetic subjects suggest that reduced availability of neurotrophic factors may contribute to the pathogenesis of diabetic neuropathy. One way to reverse this effect is to take advantage of the finding that bone marrow derived mesenchymal stem cells (BM-MSCs) promote peripheral nerve repair and the functioning of neurotrophic factors. Therefore, we speculated that treatment with BM-MSCs could be a viable therapeutic strategy for diabetic neuropathy. The present study was designed to examine the possible beneficial effect of BM-MSCs on functions of neurotrophic factors in diabetic neuropathy. To assess this possibility, we used an in vivo streptozotocin-induced diabetic neuropathy mouse model. Quantitative real-time polymerase-chain reacion showed that BM-MSCs significantly increase expression levels of neurotrophic factors. Also, BMMSCs ameliorated nerve conduction velocity in streptozotocin-treated mice. These results may help to elucidate the mechanism by which BM-MSCs function as a cell therapy agent in diabetic neuropathy.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (34)
참고문헌 신청
Ewing DJ / 1980 / The natural history of diabetic autonomic neuropathy / Q J Med 49(193):95~108
Sampson MJ / 1990 / Progression of diabetic autonomic neuropathy over a decade in insulin-dependent diabetics / Q J Med 75(278):635~646
Vinik AI / 2000 / Diabetic neuropathies / Diabetologia 43(8):957~973
Obrosova IG / 2009 / Diabetes and the peripheral nerve / Biochim Biophys Acta 1792(10):931~940
Boyd JG / 2003 / Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury / Mol Neurobiol 27(3):277~324
Sampson MJ / 1990 / Progression of diabetic autonomic neuropathy over a decade in insulin-dependent diabetics / Q J Med 75(278):635~646
Vinik AI / 2000 / Diabetic neuropathies / Diabetologia 43(8):957~973
Obrosova IG / 2009 / Diabetes and the peripheral nerve / Biochim Biophys Acta 1792(10):931~940
Boyd JG / 2003 / Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury / Mol Neurobiol 27(3):277~324
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UCI(KEPA) : I410-ECN-0101-2013-510-000557399