지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 153 - 159 (7page)
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초록· 키워드
오류제보하기
The hippocampus makes new memories and is involved in mental cognition, and the hippocampal dentate gyrus (DG) is critical because neurogenesis, which occurs throughout life, occurs in the DG. We observed the differentiation of neuroblasts into mature neurons (granule cells) in the DG of C57BL/6 mice at various early postnatal (P) ages: P1, P7, P14, and P21 using doublecortin (DCX) immunohistochemistry (IHC) for neuroblasts and calbindin D-28k (CB) IHC for granule cells. DCX-positive cells decreased in the DG with age; however, CB? cells increased over time. At P1, DCX and CB double-labeled (DCX?CB?) cells were scattered throughout the DG. At P7, DCX?CB? cells (about 92% of CB+ cells) were seen only in the granule cell layer (GCL) of the dorsal blade. At P14, DCX?CB? cells (about 66% of CB? cells) were found in the lower half of the GCL of both blades. In contrast, at P21, about 18% of CB? cells were DCX?CB? cells, and they were mainly located only in the subgranular zone of the DG. These results suggest that the developmental pattern of DCX?CB? cells changes with time in the early postnatal stages.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (36)
참고문헌 신청
Fernandes CG / Experimental evidence that phenylalanine provokes oxidative stress in hippocampus and cerebral cortex of developing rats / Cell Mol Neurobiol 30(2):317~326
He WB / 2008 / Effects of glucocorticoids on age-related impairments of hippocampal structure and function in mice / Cell Mol Neurobiol 28(2):277~291
Hwang IK / 2009 / Indole-3- propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus / J Neurosci Res 87(9):2126~2137
Kim Y / 2006 / Inductin of Neuron-derived Orphan Receptor-1 in the Dentate Gyrus of the Hippocampal Formation Following Transient Global Ischemia in the Rat / Molecules and Cells 22(1):8~12
Liu YH / 2009 / Upregulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy / Neurochem Res 34(7):1209~1218
He WB / 2008 / Effects of glucocorticoids on age-related impairments of hippocampal structure and function in mice / Cell Mol Neurobiol 28(2):277~291
Hwang IK / 2009 / Indole-3- propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus / J Neurosci Res 87(9):2126~2137
Kim Y / 2006 / Inductin of Neuron-derived Orphan Receptor-1 in the Dentate Gyrus of the Hippocampal Formation Following Transient Global Ischemia in the Rat / Molecules and Cells 22(1):8~12
Liu YH / 2009 / Upregulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy / Neurochem Res 34(7):1209~1218
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UCI(KEPA) : I410-ECN-0101-2013-510-000557379