지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 133 - 140 (8page)
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초록· 키워드
오류제보하기
Current strategies to accelerate hematopoietic reconstitution after transplantation include transplantation of greater numbers of hematopoietic stem/progenitor cells (HSPCs) or ex vivo expansion of harvested HSPCs before transplant. However, the number of cells available for transplantation is usually low, and strategies to expand HSPCs and maintain equivalent engraftment capability ex vivo are limited. We noted that activated granulocyte-derived cationic peptides positively primed responsiveness of HSPCs to a CXCL12 gradient. Accordingly, we noted that accelerated homing/engraftment of β-defensin-2, a wellknown antimicrobial cationic peptide, primed bone marrow nucleated cells (BMNCs) compared to normal BMNCs after transplantation into lethally irradiated recipients. We envision that small cationic peptides, which primarily possess antimicrobial functions and are harmless to mammalian cells, could be applied to prime HSPCs before transplantation. This novel approach would be particularly important in cord blood transplantation, where the number of HSPCs available for transplantation is usually limited.
목차
Materials and Methods
Results
Discussion
Acknowledgment
References
참고문헌 (38)
참고문헌 신청
Shi Q / 1998 / Evidence for circulating bone marrowderived endothelial cells / Blood 92(2):362~367
Rafii S / 2003 / Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration / Nat Med 9(6):702~712
Wang X / 2003 / Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells / Blood 101(10):4201~4208
Cogle CR / 2004 / Bone marrow transdifferentiation in brain after transplantation: a retrospective study / Lancet 363(9419):1432~1427
Kassirer M / 1999 / The appearance of L-selectin(low) polymorphonuclear leukocytes in the circulating pool of peripheral blood during myocardial infarction correlates with neutrophilia and with the size of the infarct / Clin Cardiol 22(11):721~726
Rafii S / 2003 / Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration / Nat Med 9(6):702~712
Wang X / 2003 / Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells / Blood 101(10):4201~4208
Cogle CR / 2004 / Bone marrow transdifferentiation in brain after transplantation: a retrospective study / Lancet 363(9419):1432~1427
Kassirer M / 1999 / The appearance of L-selectin(low) polymorphonuclear leukocytes in the circulating pool of peripheral blood during myocardial infarction correlates with neutrophilia and with the size of the infarct / Clin Cardiol 22(11):721~726
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UCI(KEPA) : I410-ECN-0101-2013-510-000557344