지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 117 - 126 (10page)
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초록· 키워드
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In oriental medicine, Liriope platyphylla (LP) has long been regarded as a curative herb useful for the treatment of diabetes, asthma, and neurodegenerative disorders. The principal objective of this study was to assess the effects of steaming time and frequency for manufactured Red LP (RLP) on insulin secretion ability and insulin receptor signaling pathway. To achieve our goal, several types of LPs manufactured under different conditions were applied to INS cells and streptozotocin (STZ)-induced diabetic ICR mice, after which alterations in insulin concentrations were detected in the culture supernatants and sera. The optimal concentration for the investigation of insulin secretion ability was found to be 50 ㎍/mL of LP. At this concentration, maximum insulin secretion was observed in the INS cells treated with LP extract steamed for 3 h (3-SLP) with two repeated steps (3 h steaming and 24 h air-dried) carried out 9 times (9-SALP); no significant changes in viability were detected in any of the treated cells. Additionally, the expression and phosphorylation levels of most components in the insulin receptor signaling pathway were increased significantly in the majority of cells treated with steaming-processed LP as compared to the cells treated with LP prepared without steaming. With regard to glucose transporter (GLUT) expression, alterations of steaming time induced similar responses on the expression levels of GLUT-2 and GLUT-3. However, differences in steaming frequency were also shown to induce dose-dependent responses in the expression level of GLUT-2 only; no significant differences in GLUT-3 expression were detected under these conditions. Furthermore, these responses observed in vitro were similarly detected in STZ-induced diabetic mice. 24-SLP and 9-SALP treatment applied for 14 days induced the down-regulation of glucose concentration and upregulation of insulin concentration. Therefore, these results indicated that the steaming processed LP may contribute to the relief of diabetes symptoms and should be regarded as an excellent candidate for a diabetes treatment.
목차
Materials and Methods
Results
Discussion
Acknowledgment
References
참고문헌 (28)
참고문헌 신청
Lee YC / 2005 / Liriopis tuber inhibit OVAinduced airway inflammation and bronchial hyperresponsiveness in murine model of asthma. / J Ethnopharmacol 101(1):144~152
허만규 / 2007 / 한국내 맥문동의 유전적 다양성과 집단 구조 / 생명과학회지 17(3):328~333
Choi SB / 2004 / The insulin sensitizing effect of homoisoflavone-enriched fraction in Liriope platyphylla Wang et Tang via PI3-kinase pathway / Life Sci 75(22):2653~2664
Jeong S / 2008 / The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARalpha action in OLETF rats / J Ethnopharmacol 119(2):245~251
Kim SW / 2002 / Inhibition of the bacterial surface protein anchoring transpeptidase sortase by medicinal plants / Biosci Biotechnol Biochem 66(12):2751~2754
허만규 / 2007 / 한국내 맥문동의 유전적 다양성과 집단 구조 / 생명과학회지 17(3):328~333
Choi SB / 2004 / The insulin sensitizing effect of homoisoflavone-enriched fraction in Liriope platyphylla Wang et Tang via PI3-kinase pathway / Life Sci 75(22):2653~2664
Jeong S / 2008 / The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARalpha action in OLETF rats / J Ethnopharmacol 119(2):245~251
Kim SW / 2002 / Inhibition of the bacterial surface protein anchoring transpeptidase sortase by medicinal plants / Biosci Biotechnol Biochem 66(12):2751~2754
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UCI(KEPA) : I410-ECN-0101-2013-510-000557324